3-甲氧基苯乙基氨基甲酸乙酯合成路线 （共 10 条）
反应条件
triethylamine in dichloromethane Acylation; 1.5 h;
参考文献
Funke, Uta; Fischer, Steffen; Hiller, Achim; Scheunemann, Matthias; Deuther-Conrad, Winnie; Brust, Peter; Steinbach, Joerg
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4727 - 4730
反应条件
1: 95 percent / H2, NH3 / Raney-Ni / ethanol / 4 h / 120 °C / 45600 Torr 2: Et3N / CH2Cl2 / 1 h View Scheme
参考文献
Weimar; Van Angerer; Wiegrebe
Archiv der Pharmazie, 1991 , vol. 324, # 8 p. 509 - 518
反应条件
1: EtOCOCl; i-Pr2EtN / acetone / 2 h / -10 °C 2: NaN3 / H2O / 5 h / 0 °C 3: toluene / 110 °C 4: 80 °C 5: 99 percent / Et3SiH / trifluoroacetic acid / 0.5 h / -10 °C View Scheme
参考文献
Masuno, Makoto N; Molinski, Tadeusz F
Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8263 - 8266
反应条件
1: NaN3 / H2O / 5 h / 0 °C 2: toluene / 110 °C 3: 80 °C 4: 99 percent / Et3SiH / trifluoroacetic acid / 0.5 h / -10 °C View Scheme
参考文献
Masuno, Makoto N; Molinski, Tadeusz F
Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8263 - 8266
反应条件
1: toluene / 110 °C 2: 80 °C 3: 99 percent / Et3SiH / trifluoroacetic acid / 0.5 h / -10 °C View Scheme
参考文献
Masuno, Makoto N; Molinski, Tadeusz F
Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8263 - 8266
反应条件
1: polyphosphoric acid / 0.08 h / 145 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / |Reflux View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1: polyphosphoric acid / 0.08 h / 145 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / |Reflux 3: hydrogen bromide / water / 3 h / |Reflux View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=25°C;
参考文献
Xu, Wei; Zhang, Xiao-Ming; Mariano, Patrick S.
Journal of the American Chemical Society, 1991 , vol. 113, # 23 p. 8863 - 8878
反应条件
PPA T=120°C; Cyclization; 1.5 h;
参考文献
Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 10 p. 2211 - 2219
反应条件
1: polyphosphoric acid / 3 h / 140 °C 2: boron tribromide / dichloromethane / 5 h / -78 - 20 °C View Scheme
参考文献
Fu, Liqiang; Liu, Xin; Ling, Chenyu; Cheng, Jianjun; Guo, Xingsheng; He, Huili; Ding, Shi; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 814 - 819
