2-(2-羟基苯基)吡啶合成路线 （共 27 条）
反应条件
2-hydroxy-1,3-isoindolinedione; [Pd{2-phenylpyridine(-H)}-μ-Cl]2; oxygen in toluene T=100°C; P=760.051 Torr; 15 h; Schlenk technique; Reagent/catalystSolvent;
参考文献
Yan, Yuepeng; Feng, Peng; Zheng, Qing-Zhong; Liang, Yu-Feng; Lu, Jing-Fen; Cui, Yuxin; Jiao, Ning
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5827 - 5831
Angew. Chem., 2013 , vol. 125, # 22 p. 5939 - 5943,5
反应条件
tetrabutyl ammonium fluoride in dichloromethane T=28°C; 3 h; Inert atmosphere; SolventConcentrationReagent/catalystTime; regioselective reaction;
参考文献
Shaibu, Balagopal S.; Kawade, Rahul Kisan; Liu, Rai-Shung
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 34 p. 6834 - 6839
反应条件
5 palladium on charcoal; ammonium formate in methanol T=95°C; Sealed tube;
参考文献
Turlington, Christopher R.; White, Peter S.; Brookhart, Maurice; Templeton, Joseph L.
Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 3981 - 3994
反应条件
toluene-4-sulfonic acid in methanol 1.5 h;
参考文献
Blume, Florian; Zemolka, Saskia; Fey, Thorsten; Kranich, Remo; Schmalz, Hans-Guenther
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 8 p. 868 - 883
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=28°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Shaibu, Balagopal S.; Kawade, Rahul Kisan; Liu, Rai-Shung
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 34 p. 6834 - 6839
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=28°C; 3 h; Inert atmosphere; regioselective reaction;
参考文献
Shaibu, Balagopal S.; Kawade, Rahul Kisan; Liu, Rai-Shung
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 34 p. 6834 - 6839
反应条件
2-hydroxy-1,3-isoindolinedione; oxygen in toluene T=100°C; P=760.051 Torr; 15 h; Schlenk technique;
参考文献
Yan, Yuepeng; Feng, Peng; Zheng, Qing-Zhong; Liang, Yu-Feng; Lu, Jing-Fen; Cui, Yuxin; Jiao, Ning
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5827 - 5831
Angew. Chem., 2013 , vol. 125, # 22 p. 5939 - 5943,5
反应条件
1.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 - 20 °C 1.2: triisopropyl borate / tetrahydrofuran / 3 h / 20 °C 2.1: 395 mg / aq. Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 15 h / 80 °C 3.1: 76 percent / p-TsOH / methanol / 1.5 h View Scheme
参考文献
Blume, Florian; Zemolka, Saskia; Fey, Thorsten; Kranich, Remo; Schmalz, Hans-Guenther
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 8 p. 868 - 883
反应条件
1: 395 mg / aq. Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 15 h / 80 °C 2: 76 percent / p-TsOH / methanol / 1.5 h View Scheme
参考文献
Blume, Florian; Zemolka, Saskia; Fey, Thorsten; Kranich, Remo; Schmalz, Hans-Guenther
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 8 p. 868 - 883
反应条件
1.1: 97 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 18 h / 20 °C 2.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 - 20 °C 2.2: triisopropyl borate / tetrahydrofuran / 3 h / 20 °C 3.1: 395 mg / aq. Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 15 h / 80 °C 4.1: 76 percent / p-TsOH / methanol / 1.5 h View Scheme
参考文献
Tschitschibabin
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920 , vol. 50, p. 516,518
Chem. Zentralbl., 1923 , vol. 94, # III p. 1022
