2-羟基-6-(2-噻吩)-4-三氟甲基烟腈合成路线 (共 4 条)
反应条件
potassium hydroxide T=25°C; neat (no solvent, solid phase); regioselective reaction;
参考文献
Journal of Sulfur Chemistry, , vol. 32, # 6 p. 611 - 622
反应条件
morpholine in ethanol 1.5 h; Heating;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 544 - 548
Zhurnal Organicheskoi Khimii, , vol. 18, # 3 p. 625 - 629
反应条件
1: sodium methylate / methanol; tetrahydrofuran / 0 - 20 °C 2: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / |Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 6 p. 1581 - 1588
反应条件
sulfuric acid T=148°C; 10 h;
参考文献
Portnoy,S.
Journal of Heterocyclic Chemistry, 1969 , vol. 6, p. 223 - 228