(S)-吡咯烷-2-羧酸乙酯盐酸盐合成路线 （共 10 条）
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Takeuchi; Yamada; Suzuki; Koizumi
Tetrahedron, 1996 , vol. 52, # 1 p. 225 - 232
反应条件
1: N-methylmorpholine / ethyl acetate / 0.25 h / Ambient temperature 2: 90 percent / ammonia / methanol / 240 h / Ambient temperature View Scheme
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. V.; Chuppin, A. V.; Trofimov, S. S.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 203 - 208
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 276 - 281
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in dichloromethane 2: With sodium hydroxide in methanol
参考文献
Ishige, Hirohide; Ishiyama, Nobuo; Mimura, Mitsuo; Hayashida, Mitsuo; Okuno, Tadashi; Ukai, Kiyoharu; Kiyofuji, Takeshi; Yoneda, Yasuo; Tauchi, Shinji; Aoyama, Akinori; Inoguchi, Kiyoshi
Heterocycles, 2006 , vol. 67, # 2 p. 561 - 566
反应条件
1: 8.5 g / NaHCO3, NaCl / CHCl3; H2O / 1.5 h / Heating 2: 63 percent / DIBAL-H / CH2Cl2; toluene / 1 h / -78 °C View Scheme
参考文献
Takeuchi; Yamada; Suzuki; Koizumi
Tetrahedron, 1996 , vol. 52, # 1 p. 225 - 232
反应条件
1: 83 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C 2: 85 percent / NaOH; HCl / methanol; CH2Cl2 / 3 h 3: 98 percent / acetic acid / 10 percent Pd/C / methanol / 2 h View Scheme
参考文献
Gudasheva; Vasilevich; Ostrovskaya; Trofimov; Voronina; Skoldinov; Rozantsev
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 562 - 567
反应条件
1: N-methylmorpholine / ethyl acetate / 0.25 h / Ambient temperature 2: 90 percent / ammonia / methanol / 240 h / Ambient temperature View Scheme
参考文献
Gudasheva, T. A.; Ostrovskaya, R. U.; Maksimova, F. V.; Chuppin, A. V.; Trofimov, S. S.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 203 - 208
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 276 - 281
反应条件
1: 83 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C
2: 85 percent / NaOH; HCl / methanol; CH2Cl2 / 3 h
View Scheme
参考文献
Gudasheva; Vasilevich; Ostrovskaya; Trofimov; Voronina; Skoldinov; Rozantsev
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 9 p. 562 - 567
反应条件
1: 60.7 percent / triethylamine / CH2Cl2 / 1 h
2: 1. H2, 2. K3Fe(CN)6 / 1. 10percent Pd/C / 1. MeOH, atmospheric pressure, room temp., 2. MeOH, phosphate buffer of pH7, ice cooling, 2-3h
View Scheme
参考文献
Singh, Rajeshwar; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 2 p. 129 - 131
反应条件
1: 60.7 percent / triethylamine / CH2Cl2 / 1 h
2: 1. sodium dithionite, 2. aq. HCl / 1. 50percent aq. THF
3: 89.4 percent / H2 / 10percent Pd/C / Ambient temperature
View Scheme
参考文献
Singh, Rajeshwar; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 2 p. 129 - 131
反应条件
1: 50 percent / triethylamine / CH2Cl2 / Ambient temperature; 1-2 h
2: 75 percent / 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide / toluene / 3 h / 80 °C
3: 77 percent / 80percent hydrazine hydrate / dioxane / 4.5 h / 100 °C
View Scheme
参考文献
Andersen,T.P.; Ghattas,A.B.; Lawesson,S.O.
Tetrahedron, 1983 , vol. 39, p. 3419
