1-(2-溴乙氧基)-4-氟苯合成路线 （共 7 条）
反应条件
sodium hydroxide in water 10 h; Reflux;
参考文献
M's Science Corporation
Patent: EP2357165 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
1: methanesulfonic acid / 18 h / Ambient temperature 2: acetic anhydride / dimethylformamide / 20 °C / 1.) 20 deg C, 2.) 50 deg C 3: 3 N NaOH / H2O / 2 h / Heating 4: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating 5: 73 percent / thionyl chloride / methanol 6: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C 7: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 95 percent / CHCl3 / Heating 2: 88 percent / HCl / ethanol View Scheme
参考文献
Tengler, Jan; Kapustikova, Iva; Stropnicky, Ondrej; Mokry, Petr; Oravec, Michal; Csoellei, Jozef; Jampilek, Josef
Central European Journal of Chemistry, 2013 , vol. 11, # 11 p. 1757 - 1767
参考文献
Julia
Bulletin de la Societe Chimique de France, 1956 , p. 185,186
反应条件
hydrogen bromide in ethanol; water
T=20°C; 48 h; Reflux;
参考文献
Guo, Xiaoke; Ma, Xianglei; Yang, Qian; Xu, Jing; Huang, Lu; Jia, Jianmin; Shan, Jiaojiao; Liu, Li; Chen, Weilin; Chu, Hongxi; Wei, Jinlian; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong
European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 89 - 94
反应条件
1: methanesulfonic acid / 18 h / Ambient temperature
2: acetic anhydride / dimethylformamide / 20 °C / 1.) 20 deg C, 2.) 50 deg C
3: 3 N NaOH / H2O / 2 h / Heating
4: 88 percent / formic acid, concd. HCl / H2O / 6 h / Heating
5: 73 percent / thionyl chloride / methanol
6: 36 percent / α-chymotrypsin / H2O; aq. HCl; NaCl / 60 h / 20 °C
7: 61 percent / acetic acid / 1.) RT, 24 h; 2.) 90 deg C, 3 h
View Scheme
参考文献
Dirlam; Moore; Urban
Journal of Organic Chemistry, 1987 , vol. 52, # 16 p. 3587 - 3591
反应条件
1: 1.) sodium / 1.) ethanol, RT, 0.5 h, 2.) ethanol, reflux, 21 h
2: 71 percent / SnCl2*2H2O, concd. HCl / ethanol / Heating
View Scheme
参考文献
Coats; Shah; Milstein; Genther; Nene; Roesener; Schmidt; Pleiss; Wagner; Baker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 57 - 63
