2,2-二甲基-2H-1-苯并吡喃-6-甲腈合成路线 （共 18 条）
反应条件
T=220°C; 0.0583333 h; Flow reactorLarge scale; Temperature;
参考文献
Bogaert-Alvarez, Ricardo J.; Demena, Paul; Kodersha, Gus; Polomski, Robert E.; Soundararajan; Wang, Steve S. Y.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 636 - 645
反应条件
3-Methylpyridine in xylene T=115°C; 24 h;
参考文献
North, Jeffrey T.; Kronenthal, David R.; Pullockaran, Annie J.; Real, Sharon D.; Chen, Helen Y.
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3397 - 3400
反应条件
hydrogenchloride in ethanol; para-xylene; ethyl acetate
反应条件
toluene-4-sulfonic acid in toluene T=100°C; 22 h;
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 23 p. 3831 - 3837
反应条件
N-benzyl-trimethylammonium hydroxide in methanol; dichloromethane; water; N,N-diethylaniline
反应条件
1: sodium hydroxide 2: AlCl3, aluminium chloride 3: pyrroline 4: potassium borohydride / methanol / 20 °C 5: trichlorophosphate / toluene View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 7, # 6 p. 415 - 420
反应条件
1: pyrrolidine / acetonitrile / 8 h / 45 °C 2: NaBH4 / methanol / 20 °C 3: p-TsOH*H2O / toluene / 22 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 23 p. 3831 - 3837
反应条件
1: NaBH4 / methanol / 20 °C 2: p-TsOH*H2O / toluene / 22 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 23 p. 3831 - 3837
反应条件
in methanol; dichloromethane; water; N,N-diethylaniline
反应条件
1: AlCl3, aluminium chloride 2: pyrroline 3: potassium borohydride / methanol / 20 °C 4: trichlorophosphate / toluene View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 7, # 6 p. 415 - 420
