4-溴-3-羟基苯甲酸乙酯合成路线 （共 6 条）
反应条件
MeSO3H; sodium hydrogencarbonate in dichloromethane; benzene
参考文献
Dawson, Marcia J.; Fontana, Joseph A.; Zhang, Xiao-kun; Leid, Mark; Jong, Ling; Hobbs, Peter D.
Patent: US2003/176506 A1, 2003 ;
反应条件
bromine; acetic acid T=20°C; 20 h;
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
sulfuric acid 22 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/89874 A1, 2004 ;
Location in patent: Page 43; 45 ;
WO 2004/089874 A1
反应条件
1: 94 percent / MeSO3H / benzene / 10 h / Heating 2: 53 percent / Br2; AcOH / 20 h / 20 °C View Scheme
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
1: 84 percent / K2CO3 / acetone / 15 h / Heating
2: 91 percent / DIBAL / CH2Cl2; hexane / 2 h / -78 °C
3: PCC / CH2Cl2 / 5 h / 20 °C
View Scheme
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
1: 84 percent / K2CO3 / acetone / 15 h / Heating
2: 91 percent / DIBAL / CH2Cl2; hexane / 2 h / -78 °C
View Scheme
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
