1-(4-氟苯基)-3-苯基脲合成路线 （共 10 条）
反应条件
1: benzoyl hydroxylamine With 4-methyl-morpholine; bromo-dimethylsulfonium bromide in 1,2-dichloro-ethane T=0°C; Lossen rearrangement; 2 h; Inert atmosphere; 2: 4-fluoroaniline in 1,2-dichloro-ethane T=0 - 80°C; Lossen rearrangement;
参考文献
Yadav, Deepak K.; Yadav, Arvind K.; Srivastava, Vishnu P.; Watal, Geeta; Yadav, Lal Dhar S.
Tetrahedron Letters, 2012 , vol. 53, # 23 p. 2890 - 2893
反应条件
potassium phosphate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide T=85°C; 16 h;
参考文献
Gavade, Sandip N.; Balaskar, Ravi S.; Mane, Madhav S.; Pabrekar, Pramod N.; Shingare, Murlidhar S.; Mane, Dhananjay V.
Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 675 - 678
反应条件
copper(I) oxide; tripotassium phosphate monohydrate T=120°C; 0.666667 h; Microwave irradiationInert atmosphereNeat (no solvent);
参考文献
Gavade, Sandip; Shingare, Murlidhar; Mane, Dhananjay
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 12 p. 4167 - 4170
反应条件
copper acetylacetonate; potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=20°C; 24 h; Inert atmosphereSealed vial;
参考文献
Gavade, Sandip; Balaskar, Ravi; Mane, Madhav; Pabrekar, Pramod N.; Mane, Dhananjay
Synthetic Communications, 2012 , vol. 42, # 11 p. 1704 - 1714
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C;
参考文献
Olma, Sebastian; Ermert, Johannes; Coenen, Heinz H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 12 p. 1037 - 1050
反应条件
copper(I) oxide; potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=100°C; 0.333333 h; Inert atmosphereMicrowave irradiation;
参考文献
Gavade, Sandip N.; Balaskar, Ravi S.; Mane, Madhav S.; Pabrekar, Pramod N.; Shingare, Murlidhar S.; Mane, Dhananjay V.
Chinese Chemical Letters, 2011 , vol. 22, # 3 p. 292 - 295
反应条件
potassium phosphate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine in N,N-dimethyl-formamide T=85°C; 24 h;
参考文献
Gavade, Sandip N.; Balaskar, Ravi S.; Mane, Madhav S.; Pabrekar, Pramod N.; Shingare, Murlidhar S.; Mane, Dhananjay V.
Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 675 - 678
反应条件
1: 83 percent / ethyldiisopropylamine / CH2Cl2 / 3 h 2: 83 percent / ethyldiisopropylamine / tetrahydrofuran / 20 °C View Scheme
参考文献
Olma, Sebastian; Ermert, Johannes; Coenen, Heinz H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 12 p. 1037 - 1050
参考文献
Miyahara
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 1950 - 1960
参考文献
Heesing,A.; Schmaldt,W.
Chemische Berichte, 1978 , vol. 111, p. 320 - 334
Full Text Show Details
Bennett; Brooks; Glasstone
Journal of the Chemical Society, 1935 , p. 1821,1825
Full Text Show Details
Mido, Yoshiyuki; Okuno, Tomoko
Journal of Molecular Structure, 1982 , vol. 82, p. 29 - 34
