3,5-双(三氟甲基)碘苯合成路线 （共 15 条）
反应条件
n-butyllithium; iodine in tetrahydrofuran; water
反应条件
sulfuric acid; iodine; fluorine in 1,2,2-trifluoro-trichloroethane Ambient temperature;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 14 p. 1659 - 1664
反应条件
copper(l) iodide; 1,10-phenanthroline; potassium iodide in methanol; water T=80°C; 3 h; High pressure;
参考文献
Organic Letters, , vol. 15, # 1 p. 140 - 143
反应条件
hydrogenchloride; potassium iodide; sodium nitrite
参考文献
Journal of the American Chemical Society, , vol. 75, p. 4967
反应条件
sulfuric acid; iodine T=55°C; 7 h;
参考文献
Journal of Fluorine Chemistry, , vol. 57, p. 307 - 321
反应条件
1: tin (II)-chloride; aqueous hydrochloric acid / Hydrogenation 2: aqueous hydrochloric acid; sodium nitrite; potassium iodide View Scheme
参考文献
Journal of the American Chemical Society, , vol. 75, p. 4967
反应条件
sulfuric acid; iodine 7 h; Ambient temperature;
参考文献
Journal of Fluorine Chemistry, , vol. 57, p. 307 - 321
反应条件
diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide 5 h; Ambient temperature;
参考文献
Wrobel, Jay; Li, Zenan; Dietrich, Arlene; McCaleb, Michael; Mihan, Brenda; Sredy, Janet; Sullivan, Donald
Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1084 - 1091
反应条件
1: 1-iodo-3,5-bis(trifluoromethyl)-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: formic acid ethyl ester in tetrahydrofuran; hexane T=-78°C; 3 h; 3: With ethanol; iodine; potassium carbonate in tetrahydrofuran; hexane T=-78 - 20°C; 16 h;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
sodium azide; CuSO4‵5H2O; sodium carbonate; sodium L-ascorbate; L-proline in water; dimethyl sulfoxide T=70°C; 24 h;
参考文献
Goriya, Yogesh; Ramana
Tetrahedron, 2010 , vol. 66, # 38 p. 7642 - 7650
