5-溴-2-氯嘧啶合成路线

参考文献

ALTANA Pharma AG
Patent: WO2007/39581 A1, 2007 ;
Location in patent: Page/Page column 31-32 ;
WO 2007/039581 A1

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/8895 A1, 2008 ;
Location in patent: Page/Page column 70 ;
WO 2008/008895 A1

110-91-8吗啉+

32779-36-55-溴-2-氯嘧啶

84539-22-05-溴-2-(吗啉-1)嘧啶

参考文献

Epple, Robert; Cow, Christopher; Xie, Yongping; Azimioara, Mihai; Russo, Ross; Wang, Xing; Wityak, John; Karanewsky, Donald S.; Tuntland, Tove; Nguyen-Tran, Van T. B.; Ngo, Cara Cuc; Huang, David; Saez, Enrique; Spalding, Tracy; Gerken, Andrea; Iskandar, Maya; Seidel, H. Martin; Tian, Shin-Shay
Journal of Medicinal Chemistry, 2010 , vol. 53, # 1 p. 77 - 105

32779-36-55-溴-2-氯嘧啶

823-89-25-溴-2-肼基嘧啶

参考文献

Salgado, Antonio; Varela, Carmen; Garcia Collazo, Ana Maria; Garcia, Fernando; Pevarello, Paolo; Alkorta, Ibon; Elguero, Jose
Journal of Molecular Structure, 2011 , vol. 987, # 1-3 p. 13 - 24

123-30-8对氨基苯酚+

32779-36-55-溴-2-氯嘧啶

76660-37-24-[(5-溴-2-嘧啶基)氧基]苯胺

参考文献

Hallur, Gurulingappa; Jimeno, Antonio; Dalrymple, Susan; Zhu, Tao; Jung, M. Katherine; Hidalgo, Manuel; Isaacs, John T.; Sukumar, Saraswati; Hamel, Ernest; Khan, Saeed R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2357 - 2360

110-89-4哌啶+

32779-36-55-溴-2-氯嘧啶

57356-64-65-溴-2-(哌啶-1-基)嘧啶

参考文献

WYETH
Patent: WO2008/73929 A1, 2008 ;
Location in patent: Page/Page column 84; 104 ;
WO 2008/073929 A1

95-48-7邻甲酚+

32779-36-55-溴-2-氯嘧啶

73267-74-05-溴-2-(o-甲苯氧基)嘧啶

参考文献

Okada; Koyanagi; Yamada; Haga
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2308 - 2315

32779-36-55-溴-2-氯嘧啶+

100-51-6苯甲醇

742058-39-52-苄氧基-5-溴嘧啶

参考文献

BAYER HEALTHCARE AG
Patent: WO2004/69805 A1, 2004 ;
Location in patent: Page 52 ;

32779-36-55-溴-2-氯嘧啶

1003845-06-42-氯嘧啶-5-硼酸

参考文献

Naseer, Muhammad Moazzam; Hameed, Shahid
Applied Organometallic Chemistry, 2012 , vol. 26, # 7 p. 330 - 334

5419-55-6硼酸三异丙酯+

32779-36-55-溴-2-氯嘧啶

1003845-06-42-氯嘧啶-5-硼酸

参考文献

NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2008/9435 A1, 2008 ;
Location in patent: Page/Page column 189-190 ;