(4-氯苯基)(环己基)甲酮合成路线 （共 14 条）
反应条件
1: 1-chloro-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: cyclohexanecarbaldehyde in tetrahydrofuran; hexane T=-78°C; 2 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 8 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
carbon monoxide; tri-ruthenium(0)dodecacarbonyl T=200°C; P=14710.2 Torr; 48 h;
参考文献
Journal of Organic Chemistry, , vol. 55, # 4 p. 1286 - 1291
反应条件
1: 71 percent / diethyl ether / -78 - 25 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 40, # 10 p. 1013 - 1021
反应条件
iron tribromide in toluene T=130°C; Wagner-Meerwein Rearrangement; 14 h; Sealed tubeSchlenk techniqueInert atmosphere; chemoselective reaction;
参考文献
Gutierrez-Bonet, Alvaro; Flores-Gaspar, Areli; Martin, Ruben
Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12576 - 12579
反应条件
tri-ruthenium(0)dodecacarbonyl; carbon monoxide T=200°C; P=14710.2 Torr; 48 h;
参考文献
Kondo, Teruyuki; Tsui, Yasushi; Watanabe, Yoshihisa
Tetrahedron Letters, 1987 , vol. 28, # 49 p. 6229 - 6230
反应条件
aluminum tri-bromide; 1,1-dibromomethane in tetrachloromethane T=0°C;
参考文献
Akhrem; Churilova; Orlinkov; Afanas'eva; Vitt; Petrovskii
Russian Chemical Bulletin, 1998 , vol. 47, # 5 p. 918 - 923
反应条件
in diethyl ether T=-78 - 25°C;
参考文献
Dar; Thiruvazhi; Abraham; Kitayama; Kopajtic; Gamliel; Slusher; Carroll; Uhl
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 10 p. 1013 - 1021
反应条件
in N,N-dimethyl-formamide T=100°C; 18 h;
参考文献
Heterocycles, , vol. 31, # 3 p. 537 - 548
反应条件
1: 96 percent / p-toluenesulfonic acid / toluene / 1 h / Heating 2: 44 percent / N-bromoacetamide (NBA), H2O / acetone / 6 h / Ambient temperature 3: 51 percent / dimethylformamide / 18 h / 100 °C View Scheme
参考文献
Heterocycles, , vol. 31, # 3 p. 537 - 548
反应条件
1: 44 percent / N-bromoacetamide (NBA), H2O / acetone / 6 h / Ambient temperature 2: 51 percent / dimethylformamide / 18 h / 100 °C View Scheme
参考文献
Heterocycles, , vol. 31, # 3 p. 537 - 548
