2-氯乙酰胺肟合成路线

参考文献

ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB
Patent: WO2008/23157 A1, 2008 ;
Location in patent: Page/Page column 122 ;
WO 2008/023157 A1

107-14-2氯乙腈+

105-56-6氰乙酸乙酯

3272-96-62-氯乙酰胺肟

参考文献

Lee, Wai Mun
Patent: US2009/112024 A1, 2009 ;
Location in patent: Page/Page column 20 ;

455-38-9间氟苯甲酸+

3272-96-62-氯乙酰胺肟

491842-63-83-(氯甲基)-5-(3-氟苯基)-1,2,4-恶二唑

参考文献

ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2004/14881 A2, 2004 ;
Location in patent: Page 105 ;
WO 2004/014881 A2

3272-96-62-氯乙酰胺肟+

1711-07-5间氟苯甲酰氯

491842-63-83-(氯甲基)-5-(3-氟苯基)-1,2,4-恶二唑

参考文献

Lankau, Hans-Joachim; Unverferth, Klaus; Grunwald, Christian; Hartenhauer, Helge; Heinecke, Kristina; Bernoester, Katrin; Dost, Rita; Egerland, Ute; Rundfeldt, Chris
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 6 p. 873 - 879

3272-96-62-氯乙酰胺肟+

149-73-5原甲酸三甲酯

51791-12-93-(氯甲基)-1,2,4-氧二唑

参考文献

Claisse,J.A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 2241 - 2249

3272-96-62-氯乙酰胺肟+

2719-27-9环己甲酰氯

189130-88-93-(氯甲基)-5-环己基-1,2,4-噁二唑

参考文献

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; DeGRADO, William, F.; WANG, Jizhou; WANG, Jun; JO, Hyunil; CANTURK, Belgin
Patent: WO2013/86131 A1, 2013 ;
Location in patent: Paragraph 0116; 0461 ;

3272-96-62-氯乙酰胺肟+

79-03-8丙酰氯

83227-01-43-(氯甲基)-5-乙基-1,2,4-噁二唑

参考文献

SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2005/68432 A1, 2005 ;
Location in patent: Page/Page column 199-200 ;

874-60-2对甲基苯甲酰氯+

3272-96-62-氯乙酰胺肟

73217-33-13-氯甲基-5-(4-甲基苯基)-1,2,4-噁二唑

参考文献

Palazzo,G. et al.
Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1469 - 1475

98-88-4苯甲酰氯+

3272-96-62-氯乙酰胺肟

1201-68-93-(氯甲基)-5-苯基-1,2,4-恶二唑

参考文献

Chiesi Farmaceutici S.p.A.; AMARI, Gabriele; Pesenti, Cristina; Bossolo, Stefano
Patent: US2013/172302 A1, 2013 ;
Location in patent: Paragraph 0136; 0137; 0138 ;

3272-96-62-氯乙酰胺肟+

98-88-4苯甲酰氯

1201-68-93-(氯甲基)-5-苯基-1,2,4-恶二唑

参考文献

Malamas, Michael S.; Sredy, Janet; Gunawan, Iwan; Mihan, Brenda; Sawicki, Diane R.; Seestaller, Laura; Sullivan, Donald; Flam, Brenda R.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 995 - 1010