3-氨基-3-(4-氟苯基)丙酸合成路线 （共 11 条）
反应条件
ammonium formate in ethanol 6 h; Reflux;
参考文献
Bea, Han-Seop; Park, Hye-Jeong; Lee, Sang-Hyeup; Yun, Hyungdon
Chemical Communications, 2011 , vol. 47, # 20 p. 5894 - 5896
反应条件
ammonium acetate; malonic acid in ethanol
反应条件
ammonium acetate in ethanol 6 h; Heating;
参考文献
Tan; Weaver
Tetrahedron, 2002 , vol. 58, # 37 p. 7449 - 7461
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kong, Xianqi; Wu, Xinfu; Bouzide, Abderrahim; Valade, Isabelle; Migneault, David; Bellini, Francesco
Patent: US2006/183800 A1, 2006 ;
Location in patent: Page/Page column 67-68 ;
反应条件
sodium hydroxide in water T=40°C; pH=11; 8 h;
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Sulyok; Gibson; Goodman; Hoelzemann; Wiesner; Kessler
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1938 - 1950
反应条件
0.5 h; Ambient temperature;
参考文献
Quermonne; Dallemagne; Louchahi-Raoul; Pilo; Rault; Robba
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 9 p. 961 - 965
反应条件
1: 71 percent / triethylamine / H2O; acetone / a) -5 deg C, 2 h, b) RT, 3 h 2: 73 percent / aq. KOH / Ambient temperature; penicillin acylase (EC 3.5.1.11), pH 7.5 View Scheme
参考文献
Li, Dengchao; Ji, Lilian; Wang, Xinfeng; Wei, Dongzhi
Preparative Biochemistry and Biotechnology, 2013 , vol. 43, # 2 p. 207 - 216
反应条件
1: 71 percent / triethylamine / H2O; acetone / a) -5 deg C, 2 h, b) RT, 3 h 3: 6 N aq. HCl / 11 h / 50 °C View Scheme
参考文献
Wu, Bian; Szymanski, Wiktor; De Wildeman, Stefaan; Poelarends, Gerrit J.; Feringa, Ben L.; Janssen, Dick B.
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 9 p. 1409 - 1412
反应条件
recombinant Alcaligenes faecalis penicillin G acylase in aq. phosphate buffer T=25°C; pH=11; 1.5 h; Enzymatic reaction; enantioselective reaction;
参考文献
Li, Dengchao; Ji, Lilian; Wang, Xinfeng; Wei, Dongzhi
Preparative Biochemistry and Biotechnology, 2013 , vol. 43, # 2 p. 207 - 216
