1-苯基-4-戊烯-1-酮合成路线 （共 116 条）
反应条件
1: With iodine; magnesium in tetrahydrofuran
T=20°C; Inert atmosphere;
2: With Jone's reagent in water
T=0°C; 2 h;
参考文献
Duan, Xiao-Yong; Zhou, Neng-Neng; Fang, Ran; Yang, Xiu-Long; Yu, Wei; Han, Bing
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3158 - 3162
Angew. Chem., 2014 , vol. 53, # 12 p. 3158 - 3162,5
反应条件
in tetrahydrofuran
T=-45 - 20°C; 14 h;
参考文献
Hansford, Karl A.; Dettwiler, James E.; Lubell, William D.
Organic Letters, 2003 , vol. 5, # 25 p. 4887 - 4890
反应条件
1: 1.) ethylmagnesium bromide, 3.) aq. HCl / 1) THF, reflux, 1 h; 2) reflux, 18 h; 3) reflux, 3 h
2: 2-methyl-propan-2-ol / Irradiation
View Scheme
参考文献
Wagner, Peter J.; Liu, Kou-Chang; Noguchi, Y.
Journal of the American Chemical Society, 1981 , vol. 103, # 13 p. 3837 - 3841
反应条件
titanium tetrachloride; zinc in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Guo, Hongyun; Ye, Suming; Wang, Junquan; Zhang, Yongmin
Journal of Chemical Research - Part S, 1997 , # 3 p. 114 - 114
反应条件
in diethyl ether
T=-30°C; 3 h; also in THF, at -50 deg C;
参考文献
Thomas, Edward W.; Szmuszkovicz, Jaqueline R.
Journal of Organic Chemistry, 1990 , vol. 55, # 24 p. 6054 - 6058
反应条件
1.1: TiCl4 / CH2Cl2 / 0.5 h
1.2: CH2Cl2 / 1 h / -78 °C
View Scheme
参考文献
Yadav, Veejendra K.; Balamurugan, Rengarajan
Organic Letters, 2003 , vol. 5, # 23 p. 4281 - 4284
反应条件
1: CCl4 / 1 h / Heating; N2
2: NaH, O2 / CCl4 / 2 h
View Scheme
参考文献
Miyashi,T.; Nishizawa,Y.; Fujii,Y.
Journal of the American Chemical Society, 1986 , vol. 108, p. 1617
反应条件
1: With (1-butene)ZrCp2 in tetrahydrofuran; hexane
T=-78 - 20°C; 49 h;
2: With water in tetrahydrofuran; hexane
参考文献
Kitamura, Mitsuru; Shintaku, Yuki; Kudo, Daisuke; Okauchi, Tatsuo
Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4890 - 4893
反应条件
1: With (1-butene)ZrCp2 in tetrahydrofuran; hexane
T=-78 - 20°C; 49 h;
2: With water in tetrahydrofuran; hexane
参考文献
Kitamura, Mitsuru; Shintaku, Yuki; Kudo, Daisuke; Okauchi, Tatsuo
Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4890 - 4893
反应条件
1: With (1-butene)ZrCp2 in hexane; toluene
T=-78 - 20°C; 3 h;
2: With water in hexane
参考文献
Kitamura, Mitsuru; Shintaku, Yuki; Kudo, Daisuke; Okauchi, Tatsuo
Tetrahedron Letters, 2010 , vol. 51, # 37 p. 4890 - 4893
