3-环丙基-3-氧代丙酸甲酯合成路线 （共 19 条）
反应条件
methanesulfonic acid in isopropyl alcohol T=80 - 87°C; 8 h;
参考文献
SUMIKA FINE CHEMICALS Co., Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP1375487 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
in isopropyl alcohol T=79 - 87°C; 4 - 10 h;
参考文献
SUMIKA FINE CHEMICALS Co., Ltd.; Nissan Chemical Industries, Ltd.
Patent: EP1375487 A1, 2004 ;
Location in patent: Page 5-6 ;
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C 3: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 10 p. 2727 - 2743
反应条件
1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2: DIBAL-H / toluene / 2 h / 0 °C View Scheme
参考文献
MSN Laboratories Limited
Patent: US2012/16129 A1, 2012 ;
反应条件
1.1: sulfuric acid / water; methanol / 22.25 h / 25 - 65 °C 1.2: 0.75 h / 0 - 25 °C / pH 6 2.1: toluene / 5 h / 25 °C / Inert atmosphere 2.2: 3 h 2.3: 2 h / 40 °C 3.1: potassium carbonate / dimethyl sulfoxide / 7 h / 75 °C View Scheme
反应条件
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2.1: DIBAL-H / toluene / 2 h / 0 °C 3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 4.2: tetrahydrofuran; hexane / -78 °C 5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C 6.1: 83.5 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 3 h / -10 °C View Scheme
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
1.1: 73.9 percent / conc. sulfuric acid / acetic acid / 10 h / 100 °C 2.1: DIBAL-H / toluene / 2 h / 0 °C 3.1: 56.5 percent / pyridinium chlorochromate; sodium acetate / CH2Cl2 / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C 4.2: tetrahydrofuran; hexane / -78 °C 5.1: 1.06 g / p-toluenesulfonic acid / tetrahydrofuran; H2O / 24 h / 20 °C View Scheme
参考文献
Suzuki; Iwasaki; Fujikawa; Kitahara; Sakashita; Sakoda
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 10 p. 2727 - 2743
反应条件
1: ammonium acetate / methanol / 48 h / 25 °C
2: toluene / 20 h / 100 °C
3: sodium t-butanolate / 30 h / 145 °C
4: phenylphosphoric acid dichloride / 0.17 h / 180 °C
5: sodium hydroxide / methanol; water / 3 h / 25 °C
View Scheme
参考文献
Scott, James S.; Gill, Adrian L.; Godfrey, Linda; Groombridge, Sam D.; Rees, Amanda; Revill, John; Schofield, Paul; Soerme, Pernilla; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6756 - 6761
参考文献
Anderson, Kevin William; Fotouhi, Nader; Gillespie, Paul; Goodnow, Robert Alan; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Myers, Michael Paul; Pietranico-Cole, Sherrie Lynn; Qi, Lida; Rossman, Pamela Loreen; Scott, Nathan Robert; Thakkar, Kshitij Chhabilbhai; Tilley, Jefferson Wright; Zhang, Qiang
Patent: US2007/225280 A1, 2007 ;
Location in patent: Page/Page column 65 ;
US 20070225280 A1
