4'-氯-2,2,2-三氟苯乙酮合成路线 （共 31 条）
反应条件
(i) Mg, (ii) /BRN= 742035/; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 25, p. 473 - 474
反应条件
1: AlCl3 2: K2CO3 View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , p. 591 - 595
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 3 p. 614 - 618
反应条件
magnesium ester of trifluoroacetic acid as aduct; Multistep reaction;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 317 - 324
Zhurnal Organicheskoi Khimii, , vol. 18, # 2 p. 365 - 373
反应条件
(i) Mg, Et2O, (ii) /BRN= 746197/; Multistep reaction;
参考文献
Journal of medicinal chemistry, , vol. 9, # 2 p. 176 - 178
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: 4'-Chloro-2,2,2-trifluoroacetophenone in tetrahydrofuran; diethyl ether T=20°C; 2 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
1: Nafion-H SAC-13 / toluene / 24 h / 185 °C 2: hydrogenchloride; water / diethyl ether / 24 h / 20 °C View Scheme
参考文献
Prakash, G.K. Surya; Glinton, Kevin E.; Panja, Chiradeep; Gurung, Laxman; Battamack, Patrice T.; Toeroek, Bela; Mathew, Thomas; Olah, George A.
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 607 - 611
参考文献
Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17692 - 17697
反应条件
hexafluoroisopropyl alcohol; 3-chloro-benzenecarboperoxoic acid in phosphate buffer; dichloromethane
T=20°C; Baeyer-Villiger oxidation; pH=7.6; 0.166667 h;
参考文献
Kobayashi, Satoru; Tanaka, Hiroaki; Amii, Hideki; Uneyama, Kenji
Tetrahedron, 2003 , vol. 59, # 9 p. 1547 - 1552
反应条件
tetrabutylammomium bromide; triethylamine in acetonitrile
T=0°C; Substitution; Electrochemical reactionPb cathode, C anode;
参考文献
Uneyama, Kenji; Mizutani, Go; Maeda, Kazushige; Kato, Tsuyoshi
Journal of Organic Chemistry, 1999 , vol. 64, # 18 p. 6717 - 6723
反应条件
tributylphosphine in toluene
T=20°C; 48 h;
参考文献
Shi, Min; Liu, Xu-Guang; Guo, Ying-Wen; Zhang, Wen
Tetrahedron, 2007 , vol. 63, # 51 p. 12731 - 12734
