暂无反应条件数据

1: 84 percent / pyridine, piperidine / 3 h / 120 °C 2: 71 percent / sodium borohydride / methanol / 1.) 5 deg C, 15 min, 2.) 20 deg C, 0.5 h 3: 1.82 g / TsOH*Py / acetone; H2O / 2 h / Heating 4: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 1 h, 2.)a) THF, hexane, -78 deg C, 1 h, b) 20 deg C, 15 h 5: 71 percent / lithium iodide / dimethylformamide / 4 h / 150 °C View Scheme

1: 1.) LDA / 1.) THF, hexane, -75 deg C, 40 min, 2.)a) THF, hexane, -70 deg C, 1 h, b) 20 deg C, 1 h 2: 3.42 g / TsOH*Py / acetone; H2O / 2 h / Heating 3: 1.) butylithium / 1.) THF, hexane, -78 deg C, 1 h, 2.)a) THF, hexane, -78 deg C, 1 h, b) 20 deg C, 15 h View Scheme

1: 84 percent / pyridine, piperidine / 3 h / 120 °C 2: 71 percent / sodium borohydride / methanol / 1.) 5 deg C, 15 min, 2.) 20 deg C, 0.5 h 3: 1.82 g / TsOH*Py / acetone; H2O / 2 h / Heating 4: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 1 h, 2.)a) THF, hexane, -78 deg C, 1 h, b) 20 deg C, 15 h 5: sodium hydroxide / H2O; methanol / 2 h / Heating 6: quinoline / Heating View Scheme

hydrogenchloride; ethanol

暂无反应条件数据

1: 1.) LDA / 1.) THF, hexane, -75 deg C, 40 min, 2.)a) THF, hexane, -70 deg C, 1 h, b) 20 deg C, 1 h 2: 3.42 g / TsOH*Py / acetone; H2O / 2 h / Heating 3: 1.) butylithium / 1.) THF, hexane, -78 deg C, 1 h, 2.)a) THF, hexane, -78 deg C, 1 h, b) 20 deg C, 15 h 4: 82 percent / H2 / Pt-black / ethanol / Ambient temperature View Scheme

1: 84 percent / pyridine, piperidine / 3 h / 120 °C 2: 71 percent / sodium borohydride / methanol / 1.) 5 deg C, 15 min, 2.) 20 deg C, 0.5 h 3: 1.82 g / TsOH*Py / acetone; H2O / 2 h / Heating 4: 1.) butyllithium / 1.) THF, hexane, -78 deg C, 1 h, 2.)a) THF, hexane, -78 deg C, 1 h, b) 20 deg C, 15 h View Scheme

1: 52 percent / LDA / tetrahydrofuran; hexane / 1) -75 deg C, 1 h, 2) 20 deg C, 1 h 2: 67 percent / NH3, Li / diethyl ether / 1.5 h / -40 °C 3: 83 percent / NaH / dimethylsulfoxide / 17 h / 20 °C 4: aq. pyridinium tosylate / acetone / 2 h / Heating 5: 1.) BuLi / 1.) THF, hexane, 2.) THF, hexane, a) -75 deg C, 1 h, b) 20 deg C, 14 h View Scheme

bei 1/4-stuendigem Kochen;