5-甲基-3-异噁唑羧酸乙酯合成路线 （共 26 条）
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
1: 34 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 4 h / 95 °C
2: K2CO3 / dimethylformamide / 1 h / 60 °C
View Scheme
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
反应条件
in isopropyl alcohol
参考文献
Gardner,T.S. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 503 - 513
反应条件
n-butyllithium
Yield given. Multistep reaction;
参考文献
Micetich, Ronald G.; Shaw, Chia C.; Hall, Tse W.; Spevak, Paul; Fortier, Robert A.; et al.
Heterocycles, 1985 , vol. 23, # 3 p. 571 - 583
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=95°C; 4 h;
参考文献
Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000
参考文献
Gardner,T.S. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1960 , vol. 2, p. 133 - 145
