2-甲基-4-苯基-1,3-噻唑-5-羧酸合成路线 （共 6 条）
反应条件
potassium hydroxide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; water
参考文献
NIHON NOHYAKU CO., LTD.
Patent: EP761658 A1, 1997 ;
反应条件
2: aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Maier,K.A.; Hromatka,O.
Monatshefte fuer Chemie, 1971 , vol. 102, p. 102 - 107
反应条件
1.1: PhI(ODNs)OH / acetonitrile / 0.01 h / 120 °C 1.2: 0.02 h / |Microwave irradiation 2.1: sodium hydroxide / ethanol / 1 h / 20 - 40 °C 2.2: 0 °C / pH 2 View Scheme
参考文献
Choi, Min Jeong; No, Eun Sun; Thorat, Dhanaji Achyutrao; Jang, Jae Wan; Yang, Hakkyun; Lee, Jaeick; Choo, Hyunah; Kim, Soo Jin; Lee, Chang Sik; Ko, Soo Young; Lee, Jiyoun; Nam, Ghilsoo; Pae, Ae Nim
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9008 - 9018
反应条件
tetraphosphorus decasulfide
参考文献
Chow,A.W. et al.
Journal of Medicinal Chemistry, 1966 , vol. 9, p. 551 - 555
反应条件
isopropyl alcohol Behandeln des Reaktionsprodukts mit wss.-aethanol. NaOH;
参考文献
Knott
Journal of the Chemical Society, 1947 , p. 1656,1658
反应条件
1: thionyl chloride / toluene / Heating
2: pyridine / CH2Cl2 / 0 °C
View Scheme
参考文献
Herrero, M.Teresa; Tellitu, Imanol; Dominguez, Esther; Hernandez, Susana; Moreno, Isabel; SanMartin, Raul
Tetrahedron, 2002 , vol. 58, # 42 p. 8581 - 8589
