4-硝基-2-(三氟甲基)苯腈合成路线 (共 5 条)
反应条件
in N,N-dimethyl-formamide T=160°C; 18 h;
参考文献
Seo, Myungeun; Seo, Gon; Sang, Youl Kim
Angewandte Chemie - International Edition, 2006 , vol. 45, # 38 p. 6306 - 6310
反应条件
hydrogenchloride; sodium nitrite in water; sodium hydrogencarbonate; acetic acid
参考文献
Novo Nordisk A/S
Patent: US5061706 A1, 1991 ;
反应条件
1: 2-Amino-5-nitrotrifluoromethylbenzene With sulfuric acid in water 2: With sodium nitrite in water T=0°C; 0.333333 h; 3: potassium cyanide With sodium carbonate; copper(II) sulfate more than 3 stages;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/13115 A2, 2004 ;
Location in patent: Page/Page column 22 ;
反应条件
1: aqueous H2SO4 / 182 °C 2: iron; aqueous NH4Cl View Scheme
参考文献
Hauptschein et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 1051,1054
反应条件
sulfuric acid; water T=165°C; 2 h;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/13115 A2, 2004 ;
Location in patent: Page/Page column 22-23 ;