Multistep reaction;

Multistep reaction;

1: 1-hydroxybut-2-yne With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78 - 0°C; Inert atmosphere; 2: With Schwartz's reagent in tetrahydrofuran; hexane T=23°C; 3 h; Inert atmosphere; 3: ethyl cis-3-bromoacrylate With C32H40Cl3N3Pd(1-) in tetrahydrofuran; hexane T=23°C; 4 h; Inert atmosphere;

Multistep reaction;

1: propargyl alcohol With diisobutylaluminium hydride in hexane T=-78°C; Inert atmosphere; 2: With zirconocene dichloride; diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78 - 23°C; 0.5 h; Inert atmosphere; 3: ethyl cis-3-bromoacrylate With C32H40Cl3N3Pd(1-) in tetrahydrofuran; hexane T=23°C; 4 h; Inert atmosphere;