(5-氟-1H-吲哚-3-基)乙酸乙酯合成路线 （共 5 条）
反应条件
1: 5-fluoro-1H-indole With n-butyllithium in tetrahydrofuran; hexane T=0°C; 0.25 h; 2: With zinc(II) chloride in tetrahydrofuran; diethyl ether; hexane 24 h; 3: ethyl bromoacetate in toluene 24 h;
参考文献
Boularot, Adrien; Giglione, Carmela; Petit, Sylvain; Duroc, Yann; De Sousa, Rodolphe Alves; Larue, Valery; Cresteil, Thierry; Dardel, Frederic; Artaud, Isabelle; Meinnel, Thierry
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 10 - 20
反应条件
1: 6 M NaOH / ethanol / 1 h / Heating 2: 1 M HCl / 1.5 h / Heating 3: Cu2Cr2O5 / quinoline / 2 h / Heating View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 1 M HCl / 1.5 h / Heating 2: Cu2Cr2O5 / quinoline / 2 h / Heating View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 1.) 12 M HCl, NaNO2, 2.) 6 M KOH, 3.) H2SO4 2: 6 M NaOH / ethanol / 1 h / Heating 3: 1 M HCl / 1.5 h / Heating 4: Cu2Cr2O5 / quinoline / 2 h / Heating View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
sodium hydroxide in ethanol 1 h; Heating;
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
