2-氨基-3-甲氧基苯甲酸合成路线 （共 68 条）
反应条件
1: 1.) NaNO2, conc. HCl, 2.) Na2S2 / 1.) H2O, 5 deg C, 2.) H2O
2: conc. H2SO4 / 1.) RT, overnight, 2.) 60 deg C, 2 h
3: 300 mg / pyridine / 20 h / Heating
4: 48percent HI / 20 h / Heating
View Scheme
参考文献
Archer; Miller; Rej; Periana; Fricker
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 220 - 227
反应条件
N-bromosuccinmide in methanol
T=-5 - 0°C;
参考文献
Glaxo Group Limited
Patent: US2009/197871 A1, 2009 ;
Location in patent: Page/Page column 52-53 ;
US 20090197871 A1
反应条件
1: dioxane / 1 h / 20 °C
2: NaH / dimethylformamide / 5 h / 20 °C
View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
1: With hydrogen bromide; sodium nitrite in water
T=-5°C; 0.166667 h;
2: With hydrogen bromide; copper(I) bromide in water
T=20°C; Sandmeyer reaction; 4 h; Heating;
参考文献
Huszthy, Peter; Koentoes, Zoltan; Vermes, Borbala; Pinter, Aron
Tetrahedron, 2001 , vol. 57, # 23 p. 4967 - 4975
反应条件
1-methyl-pyrrolidin-2-one; copper; potassium carbonate; copper(I) bromide in 2-ethoxy-ethanol
T=150°C; 2 h;
参考文献
Denny; Atwell; Baguley
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 363 - 367
反应条件
copper; potassium carbonate in ethanol
1.5 h; Reflux;
参考文献
Doerner, Bernd; Kuntner, Claudia; Bankstahl, Jens P.; Bankstahl, Marion; Stanek, Johann; Wanek, Thomas; Stundner, Gloria; Mairinger, Severin; Loescher, Wolfgang; Mueller, Markus; Langer, Oliver; Erker, Thomas
Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 6073 - 6082
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetone
T=7 - 10°C; 3 h; Cooling with ice;
2: With potassium iodide in water; acetone
T=7 - 90°C;
参考文献
Chen, Ching-Huang; Lin, Yi-Wen; Kakadiya, Rajesh; Kumar, Amit; Chen, Yu-Ting; Lee, Te-Chang; Su, Tsann-Long
Tetrahedron, 2011 , vol. 67, # 33 p. 5883 - 5893
反应条件
potassium iodide; sulfuric acid; sodium nitrite in water
参考文献
Sanofi Winthrop Inc.
Patent: US5488055 A1, 1996 ;
反应条件
1: 2-amino-3-methoxy-benzoic acid With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide
T=40°C;
2: methylamine in N,N-dimethyl-formamide
T=20°C;
参考文献
Mizutani, Takashi; Nagase, Tsuyoshi; Ito, Sayaka; Miyamoto, Yasuhisa; Tanaka, Takeshi; Takenaga, Norihiro; Tokita, Shigeru; Sato, Nagaaki
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6041 - 6045
反应条件
tetrabutyl ammonium fluoride in dichloromethane
T=20°C;
参考文献
Rao, U. Narasimha; Sathunuru, Ramadas; Maguire, John A.; Biehl, Ed
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 1 p. 13 - 21
