N-FMOC-L-甘氨酸合成路线 （共 36 条）
反应条件
formic acid ethyl ester; toluene-2-sulfonic acid in triethylamine
参考文献
Gruenenthal GmbH
Patent: US2003/236429 A1, 2003 ;
Location in patent: Page 23 ;
反应条件
triethylamine; toluene-4-sulfonic acid Heating / reflux;
参考文献
Gruenenthal GmbH
Patent: US2003/236253 A1, 2003 ;
Location in patent: Page 13 ;
反应条件
triethylamine Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; WROBLESKI, Stephen T.; BROWN, Gregory D.; DOWEYKO, Lidia M.; DUAN, Jingwu; GUO, Junqing; HYNES, John; JIANG, Bin; KEMPSON, James; LIN, Shuqun; LU, Zhonghui; SPERGEL, Steven, H.; TOKARSKI, John S.; WU, Hong; YANG, Bingwei Vera
Patent: WO2012/125886 A1, 2012 ;
Location in patent: Page/Page column 78 ;
WO 2012/125886 A1
反应条件
1: With sodium formate T=20°C; 4 h; 2: With acetic anhydride T=20°C; 4 h;
参考文献
WO2014/18807 A1, ;
Paragraph 00299; 00300 ;
参考文献
Galan, Brandon R.; Kalbarczyk, Kyle P.; Szczepankiewicz, Steven; Keister, Jerome B.; Diver, Steven T.
Organic Letters, 2007 , vol. 9, # 7 p. 1203 - 1206
反应条件
potassium hydroxide in ethanol 0.166667 h; Ambient temperature;
参考文献
Yinglin, Han; Hongwen, Hu
Synthesis, 1990 , # 2 p. 122 - 124
反应条件
1H-imidazole T=60°C; 48 h;
参考文献
Suchy, Mojmir; Elmehriki, Adam A. H.; Hudson, Robert H. E.
Organic Letters, 2011 , vol. 13, # 15 p. 3952 - 3955
反应条件
sodium formate T=100°C; 1 h;
参考文献
Andersen,T.P.; Ghattas,A.B.; Lawesson,S.O.
Tetrahedron, 1983 , vol. 39, p. 3419
反应条件
acetic acid T=100°C; 10 h;
参考文献
Wang, Zikun; Bi, Xihe; Liang, Yongjiu; Liao, Peiqiu; Dong, Dewen
Chemical Communications, 2014 , vol. 50, # 30 p. 3976 - 3978
反应条件
triethylamine in methanol 1 h; Ambient temperature;
参考文献
Neveux, Muriel; Bruneau, Christian; Dixneuf, Pierre H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 5 p. 1197 - 1199
