3-甲基苯并噻吩-2-羧酸合成路线 （共 16 条）
反应条件
potassium hydroxide; nitrogen; tetrabutylammomium bromide in water
参考文献
Uniroyal Chemical Company, Inc.; Uniroyal Chemical Co./CIE.
Patent: US5965749 A1, 1999 ;
反应条件
ethylaluminum dichloride in hexane; toluene T=100°C; P=22502.3 Torr; 3 h; AutoclaveInert atmosphere; regioselective reaction;
参考文献
Nemoto, Koji; Onozawa, Satoru; Konno, Megumi; Morohashi, Naoya; Hattori, Tetsutaro
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 3 p. 369 - 371
反应条件
n-butyllithium; diethyl ether Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
参考文献
Journal of the American Chemical Society, , vol. 75, p. 3278
反应条件
diethyl ether; magnesium anschliessend Behandlung mit Chlorokohlensaeure-aethylester und Hydrolyse des Reaktionsprodukts;
参考文献
Journal of the American Chemical Society, , vol. 74, p. 2185,2187
反应条件
diethyl ether; magnesium anschliessend Behandeln mit Kohlendioxid;
参考文献
Journal of the American Chemical Society, , vol. 74, p. 2185,2187
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 4 h;
参考文献
VANDERBILT UNIVERSITY; LEE, Taekyu; PELZ, Nicholas F.; BELMAR, Johannes; BIAN, Zhiguo; OLEJNICZAK, Edward T.; FESIK, Stephen W.; CHAUDER, Brian A.
Patent: WO2014/47427 A2, 2014 ;
Location in patent: Page/Page column 233 ;
反应条件
potassium hydroxide T=120°C;
参考文献
Annali di Chimica (Rome, Italy), , vol. 43, p. 323,328
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 18 h / 0 - 20 °C / |Inert atmosphere 2: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 4 h / 20 °C View Scheme
反应条件
anschliessend Hydrolyse;
参考文献
Journal of the American Chemical Society, , vol. 74, p. 2185,2187
参考文献
Journal of the American Chemical Society, , vol. 74, p. 2185,2187
