3-[2-(3-氯苯基)乙基]-2-吡啶甲腈合成路线 （共 15 条）
反应条件
1: 3-(3-chlorophenethyl)-pyridine N-oxide With N,N-dimethylcarbamoyl chloride in acetonitrile T=35 - 40°C; 1 - 3 h; 2: sodium cyanide in water; acetonitrile T=-5 - 0°C; 3 - 4 h; 3: With sodium hydroxide in water; acetonitrile 2 - 3 h;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/6184 A2, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
trichlorophosphate in toluene 4 h; Reflux;
参考文献
Karcher, Solveigh C.; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1778 - 1782
反应条件
sodium hydroxide in water; isopropyl alcohol; trichlorophosphate
参考文献
Schering Corporation
Patent: US5700806 A1, 1997 ;
反应条件
1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 9 p. 2242 - 2244
反应条件
1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 457 - 461
反应条件
1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 9 p. 2242 - 2244
反应条件
1: With trifluorormethanesulfonic acid T=60°C; 1 h; 2: With hydrogenchloride in water T=20°C; 1 h; Heating / reflux;
参考文献
ALANTOS PHARMACEUTICALS, INC.
Patent: WO2006/116157 A2, 2006 ;
Location in patent: Page/Page column 56-57 ;
WO 2006/116157 A2
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran
参考文献
Schering Corporation
Patent: US4863931 A1, 1989 ;
反应条件
1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C View Scheme
参考文献
Schumacher, Doris P.; Murphy, Bruce L.; Clark, Jon E.; Tahbaz, Pete; Mann, Thomas A.
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2242 - 2244
反应条件
1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
参考文献
Schumacher, Doris P.; Murphy, Bruce L.; Clark, Jon E.; Tahbaz, Pete; Mann, Thomas A.
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2242 - 2244
