2-氧代-3-苯基环戊烷羧酸乙酯合成路线 （共 9 条）
反应条件
1: 2-Phenylcyclopentanone With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran; hexane T=-78 - 20°C; 3 h; 3: With water in tetrahydrofuran; hexane
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
Location in patent: Page/Page column 35-36 ;
反应条件
1.1: diethyl ether; tetrahydrofuran / 0 °C / Reflux 2.1: formic acid; dihydrogen peroxide / water / 4 h / 20 °C 3.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -78 °C 3.2: 3 h / -78 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
反应条件
1.1: diethyl ether; tetrahydrofuran / 0 °C / Reflux 2.1: formic acid; dihydrogen peroxide / water / 4 h / 20 °C 3.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -78 °C 3.2: 3 h / -78 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
反应条件
1.1: formic acid; dihydrogen peroxide / water / 4 h / 20 °C 2.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: 3 h / -78 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.
Patent: WO2012/103297 A1, 2012 ;
反应条件
sodium ethanolate Cyclization; Dieckman reaction; 168000 h; Heating;
参考文献
Larsen, Janus S.; Christensen, Lene; Ludvig, Gitte; Jorgensen, Per T.; Pedersen, Erik B.; Nielsen, Claus
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 18 p. 3035 - 3038
反应条件
1: H2SO4 2: 67 percent / NaOEt / 168000 h / Heating View Scheme
参考文献
Larsen, Janus S.; Christensen, Lene; Ludvig, Gitte; Jorgensen, Per T.; Pedersen, Erik B.; Nielsen, Claus
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 18 p. 3035 - 3038
反应条件
1: EtONa 3: aq. HCl 4: H2SO4 5: 67 percent / NaOEt / 168000 h / Heating View Scheme
参考文献
Larsen, Janus S.; Christensen, Lene; Ludvig, Gitte; Jorgensen, Per T.; Pedersen, Erik B.; Nielsen, Claus
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 18 p. 3035 - 3038
反应条件
2: aq. HCl 3: H2SO4 4: 67 percent / NaOEt / 168000 h / Heating View Scheme
参考文献
Larsen, Janus S.; Christensen, Lene; Ludvig, Gitte; Jorgensen, Per T.; Pedersen, Erik B.; Nielsen, Claus
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 18 p. 3035 - 3038
反应条件
1: potassium hydroxide / water / 20 °C 2: hydrogenchloride; water / 1 h / Reflux 3: ammonia / water / 5 h / Heating; High-pressure flask 4: trichlorophosphate / 1 h / 110 °C / Microwave irradiation View Scheme
参考文献
WO2011/14535 A1, ;
WO 2011/014535 A1
