5,5-二甲基-二氢-呋喃-2-酮合成路线 （共 98 条）
反应条件
Erhitzen im geschlossenen Rohr auf 270-280grad und Verseifen des entstandenen Nitrils;
参考文献
Blaise
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1897 , vol. 124, p. 90
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1961 , p. 1857 - 1860
反应条件
diethyl ether; sodium hydride; ethyl acetate
参考文献
Korte et al.
Chemische Berichte, 1959 , vol. 92, p. 884,890
反应条件
diethyl ether; sodium hydride
参考文献
Korte et al.
Chemische Berichte, 1959 , vol. 92, p. 884,890
反应条件
1: AlCl3, aluminium chloride / |Inert atmosphere; |Reflux
2: sodium tetrahydroborate / tetrahydrofuran / |Inert atmosphere
View Scheme
参考文献
Volbeda, Jeroen; Daniliuc, Constantin G.; Jones, Peter G.; Tamm, Matthias
Organometallics, 2013 , vol. 32, # 20 p. 5918 - 5925
参考文献
Hoegberg, Thomas; Khanna, Ish; Drake, Steven D.; Mitscher, Lester A.; Shen, Linus L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 306 - 310
反应条件
1: AlCl3 / CS2
2: polyphosphoric acid
View Scheme
参考文献
Sawa; Kato; Masuda; Hori; Fujimura
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 9 p. 1917 - 1927
反应条件
1: 74.1 percent / sodium methoxide / benzene / 1 h / Heating
2: 63.7 percent / NBS, BPO / CCl4 / 2 h / Heating
3: 96.5 percent / water / nitromethane / 2 h / Heating
4: 95.4 percent / Jones reagent / acetone / ice bath
View Scheme
参考文献
Matsuo, Keizo; Hasuike, Yoko
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2803 - 2806
