4,4-二甲基-1-戊醇合成路线 （共 37 条）
反应条件
sodium tetrahydroborate in methanol T=0 - 20°C; 1.5 h;
参考文献
BAHRENBERG, Gregor; KUEHNERT, Sven; LUCAS, Simon; SCHROEDER, Wolfgang
Patent: US2013/281452 A1, 2013 ;
Location in patent: Paragraph 0650 ;
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=20°C; 2: With hydrogenchloride; water in diethyl ether
参考文献
MERCK SHARP and DOHME LIMITED; MERCK and CO., INC.
Patent: WO2007/125364 A1, 2007 ;
Location in patent: Page/Page column 52 ;
WO 2007/125364 A1
反应条件
tri-ruthenium(0)dodecacarbonyl; 2-(dicyclohexylphosphino)-1-methyl-1H-imidazole; water; hydrogen; lithium chloride in 1-methyl-pyrrolidin-2-one T=130°C; P=60 Torr; 20 h; Autoclave; regioselective reaction;
参考文献
Fleischer, Ivana; Dyballa, Katrin Marie; Jennerjahn, Reiko; Jackstell, Ralf; Franke, Robert; Spannenberg, Anke; Beller, Matthias
Angewandte Chemie - International Edition, 2013 , vol. 52, # 10 p. 2949 - 2953
反应条件
lithium aluminium tetrahydride in diethyl ether 12 h; Heating;
参考文献
Sasse, Astrid; Ligneau, Xavier; Rouleau, Agnes; Elz, Sigurd; Ganellin, C. Robin; Arrang, Jean-Michel; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4000 - 4010
反应条件
palladium 10 on activated carbon; hydrogen in ethanol 16 h;
参考文献
BAHRENBERG, Gregor; KUEHNERT, Sven; LUCAS, Simon; SCHROEDER, Wolfgang
Patent: US2013/281452 A1, 2013 ;
Location in patent: Paragraph 0650 ;
反应条件
1-phenyl-1-propyne; Cu in tetrahydrofuran T=80°C; 12 h;
参考文献
Kim, Ju Hyun; Chung, Young Keun
Chemical Communications, 2013 , vol. 49, # 94 p. 11101 - 11103
反应条件
platinum(IV) oxide Hydrogenation;
参考文献
Bartlett; Rosen
Journal of the American Chemical Society, 1942 , vol. 64, p. 544
反应条件
lt;RhH(PEt3)3gt;; hydrogen in ethanol T=120°C; P=30400 Torr; 16 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
MacDougall, Joanna K.; Simpson, Michael C.; Green, Michael J.; Cole-Hamilton, David J.
Journal of the Chemical Society - Dalton Transactions, 1996 , # 6 p. 1161 - 1172
反应条件
tri-ruthenium(0)dodecacarbonyl; sodium formate; lithium chloride T=150°C; 24 h; AutoclaveIonic liquid;
参考文献
Mura, Manuel G.; Luca, Lidia De; Giacomelli, Giampaolo; Porcheddu, Andrea
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3180 - 3186
反应条件
hydrogen; cobalt T=120 - 160°C; P=73550.8 - 147102 Torr; Hydrieren des Reaktionproduktes am gleichen Katalysator;
参考文献
Keulemans; Kwantes; van Bavel
Recueil des Travaux Chimiques des Pays-Bas, 1948 , vol. 67, p. 302
