5-(乙酰氨基)-N,N'-双(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺合成路线 （共 20 条）
反应条件
1: With toluene-4-sulfonic acid 2: With sodium hydroxide in methanol; water T=50 - 60°C; pH=12; 3: With hydrogenchloride in methanol; water T=60°C; pH=10.5 - 11.5;
参考文献
US7754920 B1, ;
Page/Page column 5-6 ;
反应条件
triethylamine in isobutyramide T=0 - 20°C; 13 h;
参考文献
IMPERIAL INNOVATIONS LIMITED; KINGS COLLEGE LONDON; GUYS AND ST THOMAS NHS FOUNDATION TRUST
Patent: WO2007/26140 A2, 2007 ;
Location in patent: Page/Page column 23; 25 ;
反应条件
hydrogenchloride in methanol; water; dimethylammonium 2,4-dichlorophenoxyacetate
参考文献
Dibra S.p.A.
Patent: US5965772 A1, 1999 ;
反应条件
lithium hydroxide in methanol
参考文献
Abbott Laboratories
Patent: US5705692 A1, 1998 ;
反应条件
1: in acetic acid T=55 - 120°C; 2 h; 2: With methanol
参考文献
US2011/21821 A1, ;
Page/Page column 3 ;
反应条件
lithium hydroxide; dimethylammonium 2,4-dichlorophenoxyacetate in ethanol; water; ethyl acetate; acetyl chloride
反应条件
1: 5-(acetylamino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide With sodium hydride in isobutyramide T=20°C; 2: 1,3-dichloro-2-(6-(3,4,5,6-tetrahydro-2H-pyranoxy))propane in isobutyramide T=20 - 80°C; 72 h; 3: With sodium iodide in isobutyramide
参考文献
GE Healthcare AS
Patent: EP2281802 A1, 2011 ;
Location in patent: Page/Page column 3 ;
反应条件
hydrogenchloride; sodium hydroxide in 2-methoxy-ethanol; water T=20°C; 192 h; Product distribution / selectivity;
参考文献
HOVIONE CHINA HOLDING LIMITED; HU, Zhiqi; ZHANG, Huoying
Patent: WO2011/63551 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogenchloride; boric acid; potassium hydroxide in water pH=10 - 11; Industry scale; Product distribution / selectivity;
参考文献
WO2011/63551 A1, ;
Page/Page column 15-16 ;
