1: n-amyl iodide With tert.-butyl lithium in diethyl ether; pentane T=20°C; 1.5 h; 2: With copper(l) iodide in tetrahydrofuran; diethyl ether; pentane 0.166667 h; cooling; 3: propynecarboxylic acid in tetrahydrofuran; diethyl ether; pentane T=-78 - -15°C; 0.666667 h;

1: methylmagnesium bromide With zinc dibromide in diethyl ether T=25°C; 2: (E/Z)-3-iodooct-2-enoic acid With dichloro bis(acetonitrile) palladium(II) in tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide T=25°C; 12 h; Title compound not separated from byproducts;

Cl2Ru=CHPh(PCy3)[bis(1,3-Mes-2-ylimidazolidine)] in dichloromethane 6 h; Heating; Title compound not separated from byproducts;

(i) NaOMe, MeOH, (ii) aq. NaOH; Multistep reaction;

暂无反应条件数据

View Scheme

(i) Zr catalyst, (ii) nBuLi, (iii) /BRN= 1900390/; Multistep reaction;