3,4-二氢-2H-1,4-苯并噻嗪合成路线 （共 37 条）
反应条件
1: 84 percent / pyridine / -10 °C
2: 79 percent / ammonium molybdate, 30percent hydrogen peroxide / methanol; H2O / Ambient temperature; overnight
3: 100 percent / sodium methoxide / methanol / 0.17 h / 25 °C
View Scheme
参考文献
Florio, Saverio; Leng, John L.; Stirling, Charles J. M.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 237 - 240
反应条件
1: 84 percent / pyridine / -10 °C
2: 79 percent / ammonium molybdate, 30percent hydrogen peroxide / methanol; H2O / Ambient temperature; overnight
View Scheme
参考文献
Florio, Saverio; Leng, John L.; Stirling, Charles J. M.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 237 - 240
反应条件
pyridine in diethyl ether
参考文献
Prasad,R.N.; Tietje,K.
Canadian Journal of Chemistry, 1966 , vol. 44, p. 1247 - 1258
反应条件
(i) NaNO2, aq. HCl, (ii) LiAlH4, Et2O; Multistep reaction;
参考文献
Li, Peng; Zhang, Qiang; Robichaud, Albert J.; Lee, Taekyu; Tomesch, John; Yao, Wei; Beard, J. David; Snyder, Gretchen L.; Zhu, Hongwen; Peng, Youyi; Hendrick, Joseph P.; Vanover, Kimberly E.; Davis, Robert E.; Mates, Sharon; Wennogle, Lawrence P.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2670 - 2682
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane
Methylation; 168 h;
参考文献
Holland, Herbert L.; Turner, Carl D.; Andreana, Peter R.; Nguyen, Doan
Canadian Journal of Chemistry, 1999 , vol. 77, # 4 p. 463 - 471
反应条件
1: 95 percent / 24 h / Ambient temperature
2: 1) LDA / 1) THF, -78 deg C, 15 min; 2) -78 deg C to room temp.
View Scheme
参考文献
Babudri, F.; Florio, S.; Indelicati, G.; Trapani, G.
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4082 - 4087
参考文献
Fujii
Yakugaku Zasshi, 1957 , vol. 77, p. 359
Chem.Abstr., 1957 , p. 12103
