1-(4-甲基苯基)-2-吡咯烷酮合成路线 （共 19 条）
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) in tert-butyl alcohol T=110°C; 12 h;
参考文献
Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2007 , vol. 129, # 43 p. 13001 - 13007
反应条件
potassium phosphate; copper(l) iodide; glycine in 1,4-dioxane T=100°C; Goldberg reaction; 24 h;
参考文献
Deng, Wei; Wang, Ye-Feng; Zou, Yan; Liu, Lei; Guo, Qing-Xiang
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2311 - 2315
反应条件
caesium carbonate; copper(I) bromide in dimethyl sulfoxide T=75°C; Ullmann Reaction; 26 h;
参考文献
Lv, Xin; Bao, Weiliang
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3863 - 3867
反应条件
CuI; potassium carbonate in ethyl acetate
参考文献
Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.
Patent: US2003/65187 A1, 2003 ;
反应条件
CuI; potassium carbonate in ethyl acetate
参考文献
Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.
Patent: US2003/65187 A1, 2003 ;
反应条件
potassium carbonate; copper(l) iodide in toluene T=50°C; Arylation; 6 h;
参考文献
Kang, Suk-Ku; Lee, Sang-Ho; Lee, Duckhee
Synlett, 2000 , # 7 p. 1022 - 1024
反应条件
potassium tert-butylate in tetrahydrofuran T=0°C; 2 h;
参考文献
Wang, Eng Chi; Lin, Huey-Jen
Heterocycles, 1998 , vol. 48, # 3 p. 481 - 489
反应条件
carbon tetrabromide; triphenylphosphine in acetonitrile T=60°C; 3 h;
参考文献
Yang, Yong-Hua; Shi, Min
Journal of Organic Chemistry, 2005 , vol. 70, # 21 p. 8645 - 8648
反应条件
sodium ethanolate in ethanol Yield given;
参考文献
Tetrahedron Letters, , vol. 37, # 52 p. 9403 - 9406
反应条件
1: Na2HPO4 / CHCl3 2: NaOEt / ethanol / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 57, # 47 p. 9635 - 9648
