hydrogen; palladium on activated charcoal in methanol P=4654.33 Torr; 24 h;

1: With 4-methyl-morpholine in dichloromethane T=-15 - 20°C; 2: With hydrogen; palladium on activated charcoal in methanol P=4654.46 Torr; 24 h; Further stages.;

hydrogen; palladium in water; acetic acid; tert-butyl alcohol Yield given;

1: triethylamine / acetonitrile / 4 h / 20 °C 2: H2 / Pd / acetic acid; 2-methyl-propan-2-ol; H2O View Scheme

bis-(trifluoroacetoxy)-iodo-benzene in water; acetonitrile 3 h;

1: 97 percent / triethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CHCl3; tetrahydrofuran / Ambient temperature 2: 80 percent / 1N aq. NaOH / ethanol / 2 h / Ambient temperature 3: 82 percent / N-hydroxysuccinimide, N,N'-dicyclohexylcarbodiimide, NH3 / tetrahydrofuran / Ambient temperature 4: TFA / CH2Cl2 / 3 h / 0 - 20 °C 5: <bis(trifluoroacetoxy)iodo>benzene / acetonitrile; H2O / 3 h View Scheme

1: 82 percent / N-hydroxysuccinimide, N,N'-dicyclohexylcarbodiimide, NH3 / tetrahydrofuran / Ambient temperature 2: TFA / CH2Cl2 / 3 h / 0 - 20 °C 3: <bis(trifluoroacetoxy)iodo>benzene / acetonitrile; H2O / 3 h View Scheme

1: TFA / CH2Cl2 / 3 h / 0 - 20 °C 2: <bis(trifluoroacetoxy)iodo>benzene / acetonitrile; H2O / 3 h View Scheme

1: 80 percent / 1N aq. NaOH / ethanol / 2 h / Ambient temperature 2: 82 percent / N-hydroxysuccinimide, N,N'-dicyclohexylcarbodiimide, NH3 / tetrahydrofuran / Ambient temperature 3: TFA / CH2Cl2 / 3 h / 0 - 20 °C 4: <bis(trifluoroacetoxy)iodo>benzene / acetonitrile; H2O / 3 h View Scheme

n-ethyl morpholine; acetic acid in ethanol T=37°C; 2.5 h; other reagents, other times, other temp.; Product distribution;