potassium hydroxide

hydrogenchloride; diisobutylaluminium hydride in diethyl ether; hexane; water

in tetrahydrofuran; benzene 1.) 50-55 deg C, 30 min; 2.) reflux, 2 h;

1: in tetrahydrofuran; benzene T=50°C; Inert atmosphereReflux; 2: With water; ammonium chloride in tetrahydrofuran; benzene 3: With hydrogenchloride; water in tetrahydrofuran; benzene 1 h; Reflux;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '906717', constants.ctx, '0')">lithium diisopropyl amide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730763', constants.ctx, '0')">n-heptane</a> <br /> <br /> <br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '971171', constants.ctx, '0')">p-chlorobenzyl cyanide</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">DMFA</a> <br />T=0 - 20&deg;C;&nbsp;1&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '969135', constants.ctx, '0')">methyl iodide</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">DMFA</a> <br />T=0 - 40&deg;C;&nbsp;4&nbsp;h;&nbsp;<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4006754', constants.ctx, '0')">potassium hexamethylsilazane</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=75&deg;C;&nbsp;Substitution;&nbsp;2&nbsp;h;&nbsp;<br /> &nbsp;