1-(噻吩-2-基)-1,3-丁二酮合成路线 （共 16 条）
反应条件
1: 2-acetyl-thiophene With sodium ethanolate in tetrahydrofuran T=25°C; 1 h; Inert atmosphere; 2: ethyl acetate in tetrahydrofuran T=25°C; 7 h; RefluxInert atmosphere;
参考文献
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; ILLINOIS STATE UNIVERSITY; THOMAS, Craig, J.; MALONEY, David, J.; BANTUKALLU, Ganesha, Rai; SAYED, Ahmed, A.; SIMEONOV, Anton; WILLIAMS, David, L.
Patent: WO2010/19772 A2, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
tetrachlorosilane; zinc(II) chloride in dichloromethane T=25°C; 6 h;
参考文献
Elmorsy, Saad S.; Badawy, Doria S.; Khatab, Tamer K.
Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 1 p. 109 - 116
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; cataCXium®A; caesium carbonate T=60°C; P=2250.23 Torr; 36 h; GloveboxInert atmosphereAutoclave;
参考文献
Schranck, Johannes; Tlili, Anis; Alsabeh, Pamela G.; Neumann, Helfried; Stradiotto, Mark; Beller, Matthias
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12624 - 12628
反应条件
diethyl ether; sodium amide
参考文献
Journal of the American Chemical Society, , vol. 72, p. 5219
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 - 20 °C / |Inert atmosphere 2.1: titanium tetrachloride / dichloromethane / 5 h / -78 °C / |Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 0 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 16 p. 7845 - 7858
反应条件
1: titanium tetrachloride / dichloromethane / 5 h / -78 °C / |Inert atmosphere 2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 0 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 16 p. 7845 - 7858
反应条件
sodium hydride in diethyl ether; paraffin 3 h; Heating;
参考文献
Funnell, Richard A.; Meakins, G. Denis; Peach, Josephine M.; Price, Susan J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2311 - 2316
反应条件
1: 77 percent / NaOH, NH2OH*HCl / H2O / 48 h / Ambient temperature 2: NaOH / H2O / 7 h / Heating View Scheme
参考文献
Fitton, Alan O.; Patel, Rajeshkumar N.; Millar, Ross W.
Journal of Chemical Research, Miniprint, 1986 , # 4 p. 1101 - 1127
反应条件
in water pH=0.8; 4 h; Reflux; regioselective reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3038 - 3046
参考文献
Parrini
Annali di Chimica (Rome, Italy), 1957 , vol. 47, p. 929,949
