1,2-二棕榈酰-sn-丙三醇合成路线 （共 18 条）
反应条件
pyridine in dichloromethane T=60°C;
参考文献
Jensen, Tor W.; Hu, Bi-Huang; Delatore, Shara M.; Garcia, Ana Sofia; Messersmith, Phillip B.; Miller, William M.
Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15223 - 15230
反应条件
1: N,N-diisopropylethylamine / tetrahydrofuran / 0.75 h / -78 °C 2: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h 3: 30percent H2O2 / CH2Cl2 / 1 h / 0 °C 4: H2 / PtO2, Pd / acetic acid View Scheme
参考文献
Martin, Stephen F.; Josey, John A.; Wong, Yue-Ling; Dean, Daniel W.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4805 - 4820
反应条件
1: 100 percent / NEt3 / CH2Cl2 / 2 h / 0 deg C to RT 2: 100 percent / N2O4 / CH2Cl2 / 1) -60 deg C to RT, 2) RT, 10 min 3: 100 percent / H2O / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
McGuigan, Christopher; Anson, Michael S.; Swords, Bernadette
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 16 p. 2075 - 2078
反应条件
1: 1.) Et3N, POCl3, 2.) Et3N / 1.) THF, 0 deg C, 1 h; room temperature, 4 h, 2.) THF, 0 deg C, 2 h; room temperature, 12 h 2: 93 percent / TFA / CH2Cl2 / 0.75 h / Ambient temperature View Scheme
参考文献
Lindh, Ingvar; Stawinski, Jacek
Journal of Organic Chemistry, 1989 , vol. 54, # 6 p. 1338 - 1342
反应条件
1: N,N-diisopropylethylamine / tetrahydrofuran / 0.75 h / -78 °C 2: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h 3: 30percent H2O2 / CH2Cl2 / 1 h / 0 °C 4: H2 / PtO2, Pd / acetic acid View Scheme
参考文献
Martin, Stephen F.; Josey, John A.; Wong, Yue-Ling; Dean, Daniel W.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4805 - 4820
反应条件
1: β-chloroethylphosphoryl dichloride; (-)-1,2-di-O-hexadecanoyl-sn-glycerol With triethylamine in dichloromethane phosphorylation; 2: With water; triethylamine in dichloromethane Hydrolysis; 3: trimethylamine in ethanol T=70 - 80°C; Substitution; 72 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 11 p. 1659 - 1663
反应条件
1: 90 percent / Et3N / benzene / 16 h / 20 °C 2: 56 percent / Et3N / acetonitrile / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 21 p. 7727 - 7737
反应条件
1: N,N-diisopropylethylamine / tetrahydrofuran / 0.75 h / -78 °C
2: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h
3: 30percent H2O2 / CH2Cl2 / 1 h / 0 °C
4: H2 / PtO2, Pd / acetic acid
View Scheme
参考文献
Martin, Stephen F.; Josey, John A.; Wong, Yue-Ling; Dean, Daniel W.
Journal of Organic Chemistry, 1994 , vol. 59, # 17 p. 4805 - 4820
