1-溴-2-甲基-1-丙烯合成路线 （共 93 条）
反应条件
Yield given. Multistep reaction;
参考文献
Hamon, David P. G.; Massy-Westropp, Ralph A.; Newton, Josephine L.
Tetrahedron Letters, 1993 , vol. 34, # 33 p. 5333 - 5336
反应条件
lithium in tetrahydrofuran
T=25°C; 8 h;
参考文献
Ishchenko, R. I.; Veselovskii, V. V.; Moiseenkov, A. M.; Cheskis, B. A.; Kovalev, B. G.
Chemistry of Natural Compounds, 1989 , vol. 25, p. 118 - 119
Khimiya Prirodnykh Soedinenii, 1989 , # 1 p. 132 - 134
反应条件
lithium diisopropyl amide in tetrahydrofuran; diethyl ether
T=-75°C; 2 h;
参考文献
Shimizu, Nobujiro; Shibata, Fumihiro; Tsuno, Yuho
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 777 - 778
反应条件
magnesium in tetrahydrofuran
0.5 h;
参考文献
Pattenden, Gerald; Whybrow, Derek
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1046 - 1051
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With tetrakis(dimethylamino)diboron; potassium acetate in tetrahydrofuran
T=80°C; 0.5 h;
2: 1-bromo-2-methyl-1-propene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=80°C; 24 h;
参考文献
BASF SE; SCHMIDT-LEITHOFF, Joachim; PICHLMAIR, Stefan; BELLO, Charles; BASF (CHINA) COMPANY LIMITED
Patent: WO2013/14579 A1, 2013 ;
Location in patent: Page/Page column 15 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
T=80°C; 24 h; Reagent/catalyst;
参考文献
Bello, Charles S.; Schmidt-Leithoff, Joachim
Tetrahedron Letters, 2012 , vol. 53, # 46 p. 6230 - 6235,6
反应条件
in tetrahydrofuran; diethyl ether
T=0°C; 0.5 h;
参考文献
Fugami, Keigo; Hibino, Jun-ichi; Nakatsukasa, Shigeki; Matsubara, Seijiro; Oshima, Koichiro; et al.
Tetrahedron, 1988 , vol. 44, # 13 p. 4277 - 4292
反应条件
magnesium
1.) THF, reflux, 1 h; 2.) reflux, 1 h; Yield given. Multistep reaction;
参考文献
Soderquist, John A.; Lee, Shwn-Ji Hwang
Tetrahedron, 1988 , vol. 44, # 13 p. 4033 - 4042
反应条件
tri-n-butyltin methoxide; bis (triortho-tolylphosphine)palladium(II) chloride in toluene
T=100°C; 0.5 h;
参考文献
Kosugi, Masanori; Hagiwara, Isao; Sumiya, Takao; Migita, Toshihiko
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 1 p. 241 - 246
反应条件
iron(III) chloride; magnesium
1.) THF, 1 h, room temp., 2.) 1 h, 0 deg C; Yield given. Multistep reaction;
参考文献
Tanis, Steven P.; Herrinton, Paul M.
Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4572 - 4580
