N-乙氧羰基-4-哌啶酮合成路线 （共 74 条）
反应条件
boron trifluoride diethyl etherate in diethyl ether T=-30 - 20°C; 1.5 h;
参考文献
Rawson, Thomas E.; Safina, Brian; Dotson, Jennafer; Zhou, Aihe; Aliagas-Martin, Ignacio; Halladay, Jason; Liang, Jun; Rueth, Matthias; Zhu, Bing-Yan
Patent: US2007/37791 A1, 2007 ;
Location in patent: Page/Page column 54 ;
US 20070037791 A1
反应条件
1.1: 88.8 percent / BF3*Et2O / diethyl ether / -30 - 20 °C 2.1: 84 percent / aq. KOH / ethanol / 24 h / 20 °C 3.1: nBuLi / tetrahydrofuran / 2 h / -78 °C 3.2: 64.3 percent / tetrahydrofuran / -78 - 20 °C 4.1: 73.8 percent / aq. KOH; hydrazine / ethanol / Heating View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
参考文献
Janssen Pharmaceutica N.V.
Patent: US4197304 A1, 1980 ;
反应条件
in diethyl ether Addition;
参考文献
Miovi, Ivan V.; Ivanovi, Milovan D.; Vuckovic, Sonja M.; Prostran, Milica S.; Dosen-Miovi, Ljiljana; Kiricojevi, Vesna D.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 2011 - 2014
反应条件
1: 1.) H+ / 2.) heating 2: 1.) lead tetraacetate, BF3*Et2O, 2.) H2SO4 / 1.) room temperature, 2 h, 2.) H2O, 1 h. View Scheme
参考文献
Singh; Dikshit
Synthetic Communications, 1998 , vol. 28, # 1 p. 45 - 49
反应条件
bromine in chloroform
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/124746 A1, 2009 ;
Location in patent: Page/Page column 143 ;
反应条件
in chloroform; ethyl acetate
参考文献
Ube Industries, Ltd.
Patent: US6265418 B1, 2001 ;
反应条件
n-butyllithium 1.) n-hexane, THF, Et2O, -78 deg C, 1 h, 2.) n-hexane, THF, Et2O, RT, 16 h; Yield given. Multistep reaction;
参考文献
H. LUNDBECK A/S
Patent: WO2004/26855 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
2-methyl-1-bromopropane; magnesium in diethyl ether 10 h; Heating;
参考文献
Gijsen, Harrie J.M.; De Cleyn, Michel J.A.; Love, Christopher J.; Surkyn, Michel; Van Brandt, Sven F.A.; Verdonck, Marc G.C.; Moens, Luc; Cuypers, Jef; Bosmans, Jean-Paul R.M.A.
Tetrahedron, 2008 , vol. 64, # 10 p. 2456 - 2464
反应条件
sodium cyanoborohydride in methanol T=110°C; 0.183333 h; Microwave irradiation;
参考文献
Cavalluzzi, Maria Maddalena; Viale, Maurizio; Bruno, Claudio; Carocci, Alessia; Catalano, Alessia; Carrieri, Antonio; Franchini, Carlo; Lentini, Giovanni
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4820 - 4823
