2-氰基-3,5-二氟吡啶合成路线 （共 6 条）
反应条件
polyethylene glycol 8000; potassium fluoride in dimethyl sulfoxide T=160°C; 0.5 h;
参考文献
US2003/232842 A1, ;
Page 8 ;
反应条件
1: in tetrahydrofuran T=-78 - -4°C; 2: With hydrogenchloride; water in tetrahydrofuran T=0 - 20°C; 1 h; 3: With sodium hydrogencarbonate in water pH=9;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/150462 A1, 2009 ;
Location in patent: Page/Page column 80-81 ;
WO 2009/150462 A1
反应条件
1: With hydrogenchloride in 1,4-dioxane 24 h; Heating / reflux; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117050 A1, 2008 ;
Location in patent: Page/Page column 73 ;
WO 2008/117050 A1
反应条件
sulfuric acid; water T=110°C; 22 h;
参考文献
Shionogi and Co., Ltd.
Patent: EP2305672 A1, 2011 ;
Location in patent: Page/Page column 79 ;
反应条件
in methanol 1 h; Reflux;
参考文献
He, Gang; Zhang, Shu-Yu; Nack, William A.; Li, Qiong; Chen, Gong
Angewandte Chemie - International Edition, 2013 , vol. 52, # 42 p. 11124 - 11128
Angew. Chem., 2013 , vol. 125, # 42 p. 11330 - 11334,5
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-20°C; 4 h; Inert atmosphere;
2: With hydrogenchloride; methanol in tetrahydrofuran; water; toluene
pH=4 - 5;
参考文献
Cao, Bin; Wang, Yong; Ding, Kan; Neamati, Nouri; Long, Ya-Qiu
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1239 - 1245
