1-(4-氯-苯基)-2-丙炔-1-醇合成路线 （共 9 条）
参考文献
El Douhaibi, Ahmad Samih; Judeh, Zaher M. A.; Basri, Hedaya; Moussa, Ziad; Messali, Mouslim; Qi, Gao
Synthetic Communications, 2011 , vol. 41, # 4 p. 533 - 540
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -70 °C / Inert atmosphere 1.2: 1.5 h / -70 - 20 °C / Inert atmosphere 1.3: 0 °C 2.1: methanol; potassium carbonate / 12 h / 20 °C / Inert atmosphere View Scheme
参考文献
Xu, Cheng-Fu; Xu, Mei; Yang, Liu-Qing; Li, Chuan-Ying
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 3010 - 3016
反应条件
1: trimethylsilylacetylene With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: 4-chlorobenzaldehyde in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 3: With water; sodium hydroxide in tetrahydrofuran T=20°C; 1 h; Inert atmosphere;
参考文献
Fang, Ping; Hou, Xue-Long
Organic Letters, 2009 , vol. 11, # 20 p. 4612 - 4615
反应条件
[MeCNAu((1,1′-biphenyl-2-yl)-di-tert-butylphosphine)]+SbF6− in dichloromethane T=-40 - 0°C; 0.75 h; Inert atmosphere; chemoselective reaction;
参考文献
Siah, Huey-San Melanie; Kaur, Maya; Iqbal, Naseem; Fiksdahl, Anne
European Journal of Organic Chemistry, 2014 , vol. 2014, # 8 p. 1727 - 1740
反应条件
(i) NaNH2, (ii) /BRN= 385858/; Multistep reaction;
参考文献
Yura,Y.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, p. 372 - 376
反应条件
2-iodoxybenzoic acid in dimethyl sulfoxide 5 h;
参考文献
Bagley, Mark C.; Glover, Christian
Molecules, 2010 , vol. 15, # 5 p. 3211 - 3227
反应条件
lithium aluminium tetrahydride; aluminium trichloride
参考文献
Fleming, Steven A.; Carroll, Sean M.; Hirschi, Jennifer; Liu, Renmao; Pace, J. Lee; Redd, J. Ty
Tetrahedron Letters, 2004 , vol. 45, # 17 p. 3341 - 3343
反应条件
RuCl2(η-C6H6)(TPPMS) in water T=100°C; 6 h; Inert atmosphere;
参考文献
Green Chemistry, , vol. 12, # 1 p. 135 - 143
反应条件
[Cp*Ru{PhP(C6H4-o-S)2}RuCp*](OTf)2; isopropyl alcohol in 1,2-dichloro-ethane
T=60°C; 2 h;
参考文献
Yuki, Masahiro; Miyake, Yoshihiro; Nishibayashi, Yoshiaki
Organometallics, 2010 , vol. 29, # 22 p. 5994 - 6001
