(R)-2-羟基-4-苯基丁酸合成路线 （共 58 条）
反应条件
vinyl acetate in various solvent(s) T=25°C; 30 h; lipase PS; Yields of byproduct given;
参考文献
Chadha; Manohar
Tetrahedron Asymmetry, 1995 , vol. 6, # 3 p. 651 - 652
反应条件
1: With (DHQD)2AQN in diethyl ether T=-78°C; 24 h; 2: With water Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 12 p. 2870 - 2871
反应条件
sodium hydroxide in water T=20 - 70°C;
参考文献
Journal of Organic Chemistry, , vol. 70, # 10 p. 4028 - 4032
反应条件
1: 87 percent / pyridine / 6 h / 0 - 5 °C 2: 45 percent / Novozyme 435 Candida antarctica lipase B; phosphate buffer / acetone / 24 h / 30 °C / pH 7.5 3: 74 percent / K2CO3 / methanol / 5 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 12 p. 2912 - 2916
反应条件
1: 100 percent / p-toluenesulfonic acid*H2O / benzene / 5 h / Heating 2: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 3: 86 percent / KOH / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
BIS-TRIS buffer; Lactobacillus sakei DSM 20017 in water T=42°C; pH=6; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 70, # 10 p. 4028 - 4032
反应条件
[RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen bromide; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 20 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
water; Pseudomonas lipase enzyme Ambient temperature0.05 M aq. phoshate buffer (pH 7.0); Yields of byproduct given;
参考文献
Kalaritis; Regenye; Patridge; Coffen
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 812 - 815
反应条件
1: Candida antarctica lipase B (Novozyme 435) / acetone; aq. phosphate buffer / 24 h / 30 °C / pH 7.5 2: mandelate racemase EC 5.1.2.2 / various solvent(s) / 24 h / 30 °C / pH 7.5 3: Pseudomonas sp. lipase (Amano PS-C-II) / diisopropyl ether / 48 h / 25 °C 4: 85 percent / H2 / Pd/C / methanol / 0.17 h View Scheme
参考文献
Synlett, , # 12 art. no. G12405ST, p. 1936 - 1938
