4-(三氟甲基)苯甲酸甲酯合成路线 （共 48 条）
反应条件
F5I*C5H5N*FH in dichloromethane T=40°C; 48 h;
参考文献
Hara, Shoji; Monoi, Miki; Umemura, Ryosuke; Fuse, Chiaki
Tetrahedron, 2012 , vol. 68, # 49 p. 10145 - 10150,6
反应条件
1: With thionyl chloride in toluene 3 h; 2: With triethylamine T=30 - 60°C; 15 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/785 A2, 2003 ;
Location in patent: Page 24 ;
WO 2004/000785 A2
反应条件
sulfuric acid 10 h; RefluxSealed tube;
参考文献
Zou, Liang-Hua; Priebbenow, Daniel L.; Wang, Long; Mottweiler, Jakob; Bolm, Carsten
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2558 - 2563
反应条件
1: 1-trifluoromethyl-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: formic acid methyl ester in tetrahydrofuran; hexane T=-78°C; 3 h; 3: With methanol; iodine; potassium carbonate in tetrahydrofuran; hexane T=-78 - 20°C; 14 h;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
methanol; 1,1-dimethylpropan-1-ol; sodium hydride; anhydrous cobalt diacetate in tetrahydrofuran T=40°C; P=760 Torr; 15 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 60, # 26 p. 8336 - 8340
反应条件
palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide; toluene T=100°C; P=5250.53 Torr; continuous flow reactor;
参考文献
Koos, Peter; Gross, Ulrike; Polyzos, Anastasios; O'Brien, Matthew; Baxendale, Ian; Ley, Steven V.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6903 - 6908
反应条件
copper(l) iodide; 1,10-phenanthroline; potassium carbonate in diethylene glycol dimethyl ether T=35°C; 14 h; Inert atmosphere;
参考文献
Liu, Tianfei; Shen, Qilong
Organic Letters, 2011 , vol. 13, # 9 p. 2342 - 2345
反应条件
1,1-dimethylpropan-1-ol; sodium hydride; anhydrous cobalt diacetate in tetrahydrofuran T=40°C; P=760 Torr; 15 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 60, # 26 p. 8336 - 8340
反应条件
potassium fluoride; potassium phosphate; 1,10-phenanthroline; copper (I) trifluoromethane sulfonate benzene; silver carbonate in N,N-dimethyl-formamide T=45°C; Inert atmosphere;
参考文献
Chu, Lingling; Qing, Feng-Ling
Organic Letters, 2010 , vol. 12, # 21 p. 5060 - 5063
反应条件
tert.-butylhydroperoxide; [Cu(I)(CH3CN)4]PF6; sodium hydrogencarbonate in methanol; water T=0 - 20°C; 12 h;
参考文献
Ye, Yingda; Kuenzi, Stefan A.; Sanford, Melanie S.
Organic Letters, 2012 , vol. 14, # 19 p. 4979 - 4981,3
Title/Abstract Full Text Show Details
Ye, Yingda; Kuenzi, Stefan A.; Sanford, Melanie S.
Organic Letters, 2012 , vol. 14, # 19 p. 4979 - 4981
