2-(4-甲氧基苯基)-2-甲基丙酸合成路线 （共 20 条）
反应条件
pyridine hydrochloride T=170 - 190°C; 5 h;
参考文献
Palkowitz, Alan D.; Steinberg, Mitchell I.; Thrasher, K. Jeff; Reel, Jon K.; Hauser, Kenneth L.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 26 p. 4508 - 4521
参考文献
Brown,H.C.; Kim,C.J.
Journal of the American Chemical Society, 1968 , vol. 90, p. 2082 - 2096
反应条件
dipotassium peroxodisulfate; perchloric acid in water T=25°C; pH=1.0; 0.00833333 h; Irradiation;
参考文献
Bietti, Massimo; Capone, Alberto
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 618 - 629
反应条件
dipotassium peroxodisulfate; perchloric acid in water T=25°C; pH=1.0; 0.00833333 h; Irradiation;
参考文献
Bietti, Massimo; Capone, Alberto
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 618 - 629
反应条件
potassium hydroxide; water in ethylene glycol
38 h; Heating;
参考文献
Ter Wiel, Matthijs K. J.; Odermatt, Severin; Schanen, Patrick; Seiler, Paul; Diederich, Francois
European Journal of Organic Chemistry, 2007 , # 21 p. 3449 - 3462
反应条件
1: With potassium hydroxide in water; ethylene glycol
T=20 - 160°C;
2: With hydrogenchloride in ethylene glycol diethyl ether; water
pH=2;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2005/121102 A2, 2005 ;
Location in patent: Page/Page column 24-25 ;
WO 2005/121102 A2
反应条件
sodium hydroxide; ZnBr2 in methanol
参考文献
Blaschim S.p.a.
Patent: US4675418 A1, 1987 ;
反应条件
1: With sodium hydroxide in methanesulfonic acid; water
T=20°C; 6 h;
2: With hydrogenchloride in water
pH=4;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 87 ;
WO 2013/019682 A1
反应条件
1: 2-(4-methoxyphenyl)-acetic acid With lithium diisopropyl amide in n-heptane
T=0°C; 0.666667 h;
2: methyl iodide in n-heptane
T=0 - 20°C; 0.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/74495 A1, 2003 ;
Location in patent: Page/Page column 61-62 ;
WO 03/074495 A1
反应条件
lithium diisopropyl amide
参考文献
Bietti, Massimo; Capone, Alberto
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 618 - 629
