6-氨基-2-甲基苯并噻唑合成路线 （共 19 条）
反应条件
HCOONH2; palladium on activated charcoal in tetrahydrofuran; methanol T=20°C; 72 h;
参考文献
Hrobarikova, Veronika; Hrobarik, Peter; Gajdos, Peter; Fitilis, Ioannis; Fakis, Mihalis; Persephonis, Peter; Zahradnik, Pavol
Journal of Organic Chemistry, 2010 , vol. 75, # 9 p. 3053 - 3068
反应条件
1: 64 percent / H2SO4; HNO3 / 3 h / 20 °C 2: 92 percent / HCOONH2 / Pd/C / tetrahydrofuran; methanol / 72 h / 20 °C View Scheme
参考文献
Browning et al.
Proceedings of the Royal Society of London, Series B: Biological Sciences, 1931 , vol. 108, p. 119,126
参考文献
Stephens; Wibberley
Journal of the Chemical Society, 1950 , p. 3336,3340
反应条件
disulfur dichloride Reaktion ueber mehrere Stufen;
参考文献
Cassella and Co.
Patent: DE494414 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 937
反应条件
1: acetic acid 2: aqueous H2SO4 View Scheme
参考文献
Stephens; Wibberley
Journal of the Chemical Society, 1950 , p. 3336,3340
反应条件
1: pyridine 2: aq. NaOH 3: aq. HCl View Scheme
参考文献
Levkoev,I.I. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1960 , vol. 30, p. 291 - 299,311 - 319
反应条件
Diazotierung und Umsetzung mit CuCl;
参考文献
Mizuno; Adachi
Yakugaku Zasshi, 1952 , vol. 72, p. 739,742
反应条件
Diazotierung und Umsetzung mit CuBr;
参考文献
Yakugaku Zasshi, , vol. 77, p. 1161,1163, 1164
Chem.Abstr., , p. 6319
反应条件
1: 6-amino-2-methylbenzothiazole With sulfuric acid; sodium nitrite T=-2 - 2°C; 2: sodium cyanide With sodium hydroxide T=20°C; Sandmeyer reaction; 0.166667 h;
参考文献
Hrobarik, Peter; Sigmundova, Ivica; Zahradnik, Pavol
Synthesis, 2005 , # 4 art. no. P11804SS, p. 600 - 604
反应条件
1: 6-amino-2-methylbenzothiazole With hydrogenchloride; sodium nitrite T=0°C; 2: potassium cyanide With copper(II) sulfate T=50°C; 0.5 h;
参考文献
Caleta; Grdisa; Mrvos-Sermek; Cetina; Tralic-Kulenovic; Pavelic; Karminski-Zamola
Farmaco, 2004 , vol. 59, # 4 p. 297 - 305
