2-溴-6-甲氧基苯并噻唑合成路线 （共 9 条）
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=80°C; 2 h;
参考文献
Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
Patent: US2009/275624 A1, 2009 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium nitrite in water; hydrogen bromide
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5371093 A1, 1994 ;
US 5371093 A
反应条件
hydrogenchloride in acetonitrile
参考文献
Barlaam, Bernard; Bernstein, Peter; Dantzman, Cathy; Warwick, Paul
Patent: US2004/102435 A1, 2004 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethylene glycol dimethyl ether; water T=150°C; Suzuki coupling; Microwave irradiationCombinatorial reaction / High throughput screening (HTS);
参考文献
Auld, Douglas S.; Zhang, Ya-Qin; Southall, Noel T.; Rai, Ganesha; Landsman, Marc; MacLure, Jennifer; Langevin, Daniel; Thomas, Craig J.; Austin, Christopher P.; Inglese, James
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1450 - 1458
反应条件
in dimethyl sulfoxide T=110°C; 5 h;
参考文献
Suzuki, Nobutaka; Nomoto, Tateo; Toya, Yoshiaki; Kanamori, Norio; Yoda, Binkoh; Saeki, Akio
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 9 p. 1561 - 1562
反应条件
in dimethyl sulfoxide T=110°C; 5 h;
参考文献
Meroni, Giuseppe; Ciana, Paolo; Maggi, Adriana; Santaniello, Enzo
Synlett, 2009 , # 16 p. 2682 - 2684
反应条件
in dimethyl sulfoxide T=110°C; 10 h;
参考文献
Suzuki, Nobutaka; Nomoto, Tateo; Toya, Yoshiaki; Kanamori, Norio; Yoda, Binkoh; Saeki, Akio
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 9 p. 1561 - 1562
反应条件
1: With boron tribromide in dichloromethane 2: With water in dichloromethane T=20°C; 2 h;
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; CAI, Lisheng; PIKE, Victor W.
Patent: WO2013/40183 A1, 2013 ;
Location in patent: Paragraph 0062 ;
反应条件
1: With potassium carbonate in water; N,N-dimethyl-formamide
Suzuki-Miyaura Coupling; 1 h; Inert atmosphere;
2: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; N,N-dimethyl-formamide
T=80°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere; TemperatureTime;
参考文献
Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde
Tetrahedron, 2013 , vol. 69, # 35 p. 7345 - 7353
