1,4,7,10-四氮杂环十二烷合成路线 （共 64 条）
反应条件
hydrogenchloride; sodium hydroxide; bromine in water; toluene
参考文献
Bracco International B.V.
Patent: EP914320 B1, 2002 ;
反应条件
sulfuric acid T=165°C;
参考文献
Wilson, Jennifer M.; Giordani, Federica; Farrugia, Louis J.; Barrett, Michael P.; Robins, David J.; Sutherland, Andrew
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 22 p. 3651 - 3656
反应条件
ethylenediamine in water
参考文献
Bracco International B.V.
Patent: EP980360 B1, 2002 ;
反应条件
in sulfuric acid; toluene
参考文献
Bracco International B.V.
Patent: EP914320 B1, 2002 ;
反应条件
trifluoroacetic acid in dichloromethane 0.333333 h;
参考文献
Skwierawska, Anna M.
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6308 - 6310
反应条件
1: 78 percent / K2CO3 / dimethylformamide / 30 h / 100 °C 2: 33 percent / conc. H2SO4 / 28 h / 115 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 3 p. 197 - 209
反应条件
1: With hydrogenchloride; bromine in water T=20°C; Oxidation; 2: With sodium hydroxide in water Hydrolysis; 36 h; Heating;
参考文献
Ferrari, Marinella; Giovenzana, Giovanni B.; Palmisano, Giovanni; Sisti, Massimo
Synthetic Communications, 2000 , vol. 30, # 1 p. 15 - 21
反应条件
1: 90 percent / ethanol / 3 h / 0 °C 2: 50 percent / cesium carbonate / acetonitrile / 96 h / 40 °C 3: hydrochloric acid / H2O / 6 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 21 p. 3271 - 3282
反应条件
dimethylsulfide borane complex in tetrahydrofuran Hydrolysis; 48 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 1 p. 33 - 35
反应条件
10 Pd/C; cyclohexene in ethanol 1 h; Reflux;
参考文献
Tetrahedron Letters, , vol. 49, # 44 p. 6308 - 6310
