4-溴-N-羟基苯甲醛肟氯化物合成路线 （共 23 条）
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide T=35°C; Cooling with ice;
参考文献
Vo, Quan V.; Trenerry, Craige; Rochfort, Simone; Wadeson, Jenny; Leyton, Carolina; Hughes, Andrew B.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 5945 - 5954
反应条件
1: aq. NH2OH*HCl; AcONa / ethanol / 12 h 2: N-chlorosuccinimide; pyridine / CHCl3; tetrahydrofuran / 2 h View Scheme
参考文献
Wielkopolski; Smieszek; Witek; Dabrowski; Wieczorek; Lejczak; Kafarski
Pesticide Science, 1994 , vol. 40, # 2 p. 107 - 112
反应条件
1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.5 h / Sealed; Heating 2.1: potassium carbonate / ethanol / 18 h / 20 °C 3.1: hydroxylamine hydrochloride; sodium hydroxide; water / ethanol / 3 h / Cooling with ice 3.2: pH 6 4.1: N-chloro-succinimide / N,N-dimethyl-formamide / Cooling with ice; Heating View Scheme
参考文献
NOVARTIS AG; CAPPARELLI, Michael Paul; GAMBER, Gabriel G.; MEREDITH, Erik; MONOVICH, Lauren G.; RAO, Chang; SOLDERMANN, Nicolas
Patent: WO2011/9484 A1, 2011 ;
WO 2011/009484 A1
反应条件
1.1: hydroxylamine hydrochloride; sodium hydroxide; water / ethanol / 3 h / Cooling with ice 1.2: pH 6 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / Cooling with ice; Heating View Scheme
参考文献
NOVARTIS AG; CAPPARELLI, Michael Paul; GAMBER, Gabriel G.; MEREDITH, Erik; MONOVICH, Lauren G.; RAO, Chang; SOLDERMANN, Nicolas
Patent: WO2011/9484 A1, 2011 ;
WO 2011/009484 A1
反应条件
1: Et3N 2: H2SO4, NaN3 / CHCl3 View Scheme
参考文献
Bianchi,G. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 331 - 343
反应条件
triethylamine 3 h; Ambient temperature;
参考文献
Bianchi,G. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 331 - 343
参考文献
Salgado-Zamora, Hector; Campos, Elena; Jimenez, Rogelio; Cervantes, Humberto
Heterocycles, 1998 , vol. 47, # 2 p. 1043 - 1049
反应条件
1: triethylamine / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / |Inert atmosphere 2: potassium phosphate; oxygen / N,N-dimethyl-formamide / 5 h / 60 °C / 760.05 Torr View Scheme
参考文献
Zhang, Feng-Lian; Wang, Yi-Feng; Chiba, Shunsuke
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 36 p. 6003 - 6007
反应条件
OuadraPure™ Thiaurea resin; SIO2-pyridine in acetonitrile T=50°C; 0.166667 h; Flow reactor;
参考文献
Baumann, Marcus; Baxendale, Ian R.
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1613 - 1619
反应条件
OuadraPure™ Thiaurea resin; SIO2-pyridine in acetonitrile T=20°C; 1 h; Reagent/catalystSolvent;
参考文献
Baumann, Marcus; Baxendale, Ian R.
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1613 - 1619
