(2-氧代四氢呋喃-3-基)膦酸二乙酯合成路线 （共 10 条）
参考文献
Kang, Sung Ho; Kim, Geun Tae; Yoo, Yong Sang
Tetrahedron Letters, 1997 , vol. 38, # 4 p. 603 - 606
反应条件
air; lithium diisopropyl amide Yield given. Multistep reaction;
参考文献
Lee, Koo; Wiemer, David F.
Phosphorus, Sulfur and Silicon and the Related Elements, 1993 , vol. 75, # 1-4 p. 87 - 90
反应条件
other lactones; Product distribution;
参考文献
Jackson, John A.; Hammond, Gerald B.; Wiemer, David F.
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4750 - 4754
反应条件
potassium carbonate in water T=0°C; 0.25 h;
参考文献
Beji; Besbes; Amri
Synthetic Communications, 2000 , vol. 30, # 21 p. 3947 - 3954
反应条件
sodium hydride
1.) benzene, 50-60 deg C, 3 h, 2.) benzene, reflux, overnight; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gasperi, Tecla; Loreto, M. Antonietta; Tardella, Paolo A.; Veri, Elisabetta
Tetrahedron Letters, 2003 , vol. 44, # 27 p. 4953 - 4956
反应条件
potassium carbonate in tetrahydrofuran
T=20°C; Wittig-Horner reaction; 2 h; Title compound not separated from byproducts;
参考文献
Beji; Besbes; Amri
Synthetic Communications, 2000 , vol. 30, # 21 p. 3947 - 3954
反应条件
1: (2-oxotetrahydrofuran-3-yl)phosphonic acid diethyl ester With 18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: propionaldehyde in tetrahydrofuran
T=30°C; Horner-Wadsworth-Emmons reaction; 3 h; Further stages.;
参考文献
Yu, Jose S.; Wiemer, David F.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6263 - 6265
反应条件
18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran
1.) -78 deg C, 30 min, 2.) -78 deg C to r.t., 1 h then r.t., 1 h;
参考文献
Lee, Koo; Jackson, John A.; Wiemer, David F.
Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 5967 - 5971
反应条件
1: (2-oxotetrahydrofuran-3-yl)phosphonic acid diethyl ester With 18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: propionaldehyde in tetrahydrofuran
T=-78 - 20°C; Horner-Wadsworth-Emmons reaction; 3 h; Further stages.;
参考文献
Yu, Jose S.; Wiemer, David F.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6263 - 6265
反应条件
18-crown-6 ether; potassium hexamethylsilazane in tetrahydrofuran
1.) -78 deg C, 30 min, 2.) -78 deg C to r.t., 1 h then r.t., 1 h;
参考文献
Lee, Koo; Jackson, John A.; Wiemer, David F.
Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 5967 - 5971
