1H-1,2,3-三氮唑合成路线

参考文献

Wertz, Sebastian; Kodama, Shintaro; Studer, Armido
Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11511 - 11515

52548-14-82-碘-5-甲基苯甲酸+

288-36-81H-1,2,3-三氮唑

956317-36-52-(2H-1,2,3-噻唑-2-基)-5-甲基苯甲酸

参考文献

MERCK and CO., INC.
Patent: WO2008/147518 A1, 2008 ;
Location in patent: Page/Page column 32; 34 ;
WO 2008/147518 A1

288-36-81H-1,2,3-三氮唑+

52548-14-82-碘-5-甲基苯甲酸

956317-36-52-(2H-1,2,3-噻唑-2-基)-5-甲基苯甲酸

参考文献

Cox, Christopher D.; Breslin, Michael J.; Whitman, David B.; Schreier, John D.; McGaughey, Georgia B.; Bogusky, Michael J.; Roecker, Anthony J.; Mercer, Swati P.; Bednar, Rodney A.; Lemaire, Wei; Bruno, Joseph G.; Reiss, Duane R.; Harrell, C. Meacham; Murphy, Kathy L.; Garson, Susan L.; Doran, Scott M.; Prueksaritanont, Thomayant; Anderson, Wayne B.; Tang, Cuyue; Roller, Shane; Cabalu, Tamara D.; Cui, Donghui; Hartman, George D.; Young, Steven D.; Koblan, Ken S.; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5320 - 5332

288-36-81H-1,2,3-三氮唑+

6967-82-42-溴-5-甲基苯甲酸

956317-36-52-(2H-1,2,3-噻唑-2-基)-5-甲基苯甲酸

参考文献

EOLAS THERAPEUTICS, INC.; KAMENECKA, Theodore; JIANG, Rong; SONG, Xinyi
Patent: WO2013/119639 A1, 2013 ;
Location in patent: Page/Page column 153; 154 ;

288-36-81H-1,2,3-三氮唑+

108-05-4醋酸乙烯酯

41917-22-0

参考文献

Kizhnyaev; Pokatilov; Tsypina; Ratovskii; Vereshchagin; Smirnov
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 7 p. 1056 - 1059

288-36-81H-1,2,3-三氮唑+

105-36-2溴乙酸乙酯

4314-21-01H-1,2,3-噻唑-1-乙酸乙酯

参考文献

BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2010/305085 A1, 2010 ;
Location in patent: Page/Page column 25 ;
US 20100305085 A1

105-36-2溴乙酸乙酯+

288-36-81H-1,2,3-三氮唑

4314-21-01H-1,2,3-噻唑-1-乙酸乙酯+

4320-90-52H-1,2,3-噻唑-2-乙酸乙酯

参考文献

PFIZER LIMITED
Patent: WO2006/123242 A1, 2006 ;
Location in patent: Page/Page column 34 ;
WO 2006/123242 A1

288-36-81H-1,2,3-三氮唑+

105-36-2溴乙酸乙酯

4314-21-01H-1,2,3-噻唑-1-乙酸乙酯+

4320-90-52H-1,2,3-噻唑-2-乙酸乙酯

参考文献

PFIZER LIMITED
Patent: WO2006/114706 A1, 2006 ;
Location in patent: Page/Page column 50 ;
WO 2006/114706 A1

288-36-81H-1,2,3-三氮唑+

574-98-1N-(2-溴乙基)邻苯二甲酰亚胺

4396-77-4

参考文献

ELI LILLY AND COMPANY
Patent: WO2008/144223 A2, 2008 ;
Location in patent: Page/Page column 36; 37 ;

574-98-1N-(2-溴乙基)邻苯二甲酰亚胺+

288-36-81H-1,2,3-三氮唑

4396-77-4

参考文献

Sun, Li; Liang, Chris; Shirazian, Sheri; Zhou, Yong; Miller, Todd; Cui, Jean; Fukuda, Juri Y.; Chu, Ji-Yu; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Sistla, Anand; Luu, Tony C.; Tang, Flora; Wei, James; Tang, Cho
Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1116 - 1119